Potter Carol Jean
Nationwide Children's Hospital, The Ohio State University, 700 Childrens Drive, Columbus, OH 43205, USA.
Clin Perinatol. 2020 Jun;47(2):341-354. doi: 10.1016/j.clp.2020.02.009. Epub 2020 Mar 4.
Liver dysfunction is a common problem in the sick premature infant. The dysfunction is usually multifactorial and often underlies a combination of liver immaturity, comorbidities, and/or the presence of primary liver disease. The liver of the preterm infant has a paucity of bile ducts, low levels of many hepatic enzymes and transporters, and a small bile acid pool. Many other organ systems are immature as well and do not respond to stress the way they would later in infancy. This articles discusses how prematurity affects the liver, how it responds to secondary insults, and approaches to evaluation.
肝功能障碍是患病早产儿的常见问题。这种功能障碍通常是多因素的，往往是肝脏不成熟、合并症和/或原发性肝病共同作用的结果。早产儿的肝脏胆管稀少，许多肝酶和转运蛋白水平较低，胆汁酸池较小。许多其他器官系统也不成熟，对压力的反应与婴儿后期不同。本文讨论了早产如何影响肝脏、肝脏对继发性损伤的反应以及评估方法。
