酮康唑的液相色谱测定法。
Liquid chromatographic assay of ketoconazole.
作者信息
Andrews F A, Peterson L R, Beggs W H, Crankshaw D, Sarosi G A
出版信息
Antimicrob Agents Chemother. 1981 Jan;19(1):110-3. doi: 10.1128/AAC.19.1.110.
Abstract
A reverse-phase, high-pressure liquid chromatographic method for the rapid and quantitative determination of ketoconazole has been developed. Drug levels from 0.5 to 10 microgram/ml can be determined in either yeast nitrogen base medium or human serum by using an octadecylsilane column. A retention time of 4.9 +/- 0.1 min resulted when the drug was eluted from a column with 75% methanol-25% 0.02 M (pH 7.5) phosphate buffer at a flow rate of 2 ml/min. Optimum sensitivity was obtained at a wavelength of 231 nm.
摘要
已开发出一种用于快速定量测定酮康唑的反相高压液相色谱法。使用十八烷基硅烷柱，可在酵母氮碱培养基或人血清中测定0.5至10微克/毫升的药物水平。当药物以2毫升/分钟的流速从含有75%甲醇 - 25% 0.02M（pH 7.5）磷酸盐缓冲液的柱中洗脱时，保留时间为4.9 +/- 0.1分钟。在231纳米波长处获得最佳灵敏度。
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