Cell Therapy and Tissue Engineering Group, Research Institute on Health Sciences (IUNICS), University of the Balearic Islands (UIB), Ctra. Valldemossa km 7.5, 07122, Palma, Spain.
Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain.
Sci Rep. 2020 May 21;10(1):8667. doi: 10.1038/s41598-020-65826-z.
Extracellular vesicles (EVs) represent a new paradigm, both in cell biology and medicine; specifically, the idea that functional content itself may be delivered directly to cells. EVs are cell-derived membranous structures that work as intercellular communicators exerting their function by transporting their cargo that includes nucleic acids, proteins and lipids. EVs play an essential role in normal physiology, but also in pathological communication, for instance, in cancer, EVs are thought to deliver oncogenic molecules (such as proteins, peptides, RNAs…) to neighboring cells, enhancing propagation of neoplastic cells. Not surprisingly, EV research has become common-place in every field of biomedicine, being explored as diagnostics and therapeutics. This Collection gathers original Articles that investigate the application of extracellular vesicles on diagnostics and therapeutics, and that report advances in the knowledge of EV biology and the methodological tools for their study.
细胞外囊泡 (EVs) 在细胞生物学和医学领域均代表着一种新的范式；具体而言，这一概念认为功能性内容本身可以直接递送到细胞中。EVs 是由细胞衍生的膜性结构，通过运输其 cargo（包括核酸、蛋白质和脂质）来充当细胞间的通讯器，从而发挥其功能。EVs 在正常生理学中发挥着重要作用，但在病理性通讯中也是如此，例如在癌症中，人们认为 EVs 将致癌分子（如蛋白质、肽、RNAs……）递送到邻近细胞，从而增强肿瘤细胞的增殖。毫不奇怪，EV 研究已成为生物医学各个领域的常见研究课题，被探索作为诊断和治疗方法。本专集汇集了探讨细胞外囊泡在诊断和治疗中的应用的原创文章，并报告了 EV 生物学知识的进展以及研究它们的方法学工具。
