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以及其对大鼠胃肠动力的影响。 （注：原英文文本表述不完整，推测补充完整后大致是这样的意思，仅按照要求翻译现有内容）

and effects of on gastrointestinal motility in rats.

作者信息

Wang Shasha, Yan Meixing, Guo Yaoyao, Sun Runzhou, Jin Hong, Gong Yanling

机构信息

Department of Pharmacy, College of Chemical Engineering, Qingdao University of Science & Technology, Qingdao, China.

Qingdao Women and Children's Hospital, Qingdao, China.

出版信息

Iran J Basic Med Sci. 2020 Mar;23(3):383-389. doi: 10.22038/IJBMS.2019.40613.9605.

DOI:10.22038/IJBMS.2019.40613.9605
PMID:32440326
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7229513/
Abstract

OBJECTIVES

is widely distributed along the Bohai coast and consumed as an edible plant by native residents. We have found surprisingly that extracts promoted gastrointestinal motility in mice previously. In the present study, effects of on gastrointestinal motility in rats and its underlying mechanism were explored.

MATERIALS AND METHODS

, different fraction extracts from were prepared and the effects on gastric emptying and small intestinal propulsion in normal rats were measured. Plasma ghrelin (GRL), motilin (MTL), gastrin (GAS) and vasoactive intestinal peptide (VIP) and expressions of GRL receptor (GHSR), MTL receptor (MTLR), VIP receptor 2 (VIPR2) in the duodenum were also detected. , gastric antrum strips were prepared and activities of different extracts on gastric smooth muscle contractions were evaluated.

RESULTS

Results showed that the ethyl acetate extract (EAE) was the most effective fraction to promote gastric emptying and intestinal propulsion, showing a dose-dependent manner. EAE increased plasma GRL and GAS, elevated GHSR expression and restrained VIPR2 expression in the duodenum. , EAE promoted contraction of normal gastric antrum strips as well as relaxed strips induced by atropine.

CONCLUSION

These data indicate that EAE has a significant prokinetic activity via a mechanism that mainly involves in modulating plasma GRL and GAS, expressions of GSHR and VIPR2 in the duodenum and activating M-cholinergic receptor. Our study provides a pharmacological basis for the use of extract in treating gastrointestinal motility disorders.

摘要

目的

[植物名称]广泛分布于渤海沿岸，当地居民将其作为可食用植物。我们之前意外发现该植物提取物可促进小鼠胃肠道蠕动。在本研究中，探讨了该植物对大鼠胃肠道蠕动的影响及其潜在机制。

材料与方法

制备该植物不同部位的提取物，测定其对正常大鼠胃排空和小肠推进的影响。同时检测血浆胃饥饿素（GRL）、胃动素（MTL）、胃泌素（GAS）和血管活性肠肽（VIP）以及十二指肠中GRL受体（GHSR）、MTL受体（MTLR）、VIP受体2（VIPR2）的表达。此外，制备胃窦条，评估不同提取物对胃平滑肌收缩的活性。

结果

结果表明，乙酸乙酯提取物（EAE）是促进胃排空和肠推进最有效的部位，呈剂量依赖性。EAE可增加血浆GRL和GAS水平，提高十二指肠中GHSR表达并抑制VIPR2表达。此外，EAE可促进正常胃窦条收缩以及阿托品诱导的松弛胃窦条收缩。

结论

这些数据表明，EAE具有显著的促动力活性，其机制主要涉及调节血浆GRL和GAS水平、十二指肠中GSHR和VIPR2的表达以及激活M胆碱能受体。我们的研究为该植物提取物用于治疗胃肠道动力障碍提供了药理学依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c3/7229513/c45859d23cb9/IJBMS-23-383-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c3/7229513/412247ffb5b9/IJBMS-23-383-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c3/7229513/43e2d8176888/IJBMS-23-383-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c3/7229513/0c0d1d7aa979/IJBMS-23-383-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c3/7229513/6575e2e64f4f/IJBMS-23-383-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c3/7229513/886bc3003d28/IJBMS-23-383-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c3/7229513/1a046d696ead/IJBMS-23-383-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c3/7229513/c45859d23cb9/IJBMS-23-383-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c3/7229513/412247ffb5b9/IJBMS-23-383-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c3/7229513/43e2d8176888/IJBMS-23-383-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c3/7229513/0c0d1d7aa979/IJBMS-23-383-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c3/7229513/6575e2e64f4f/IJBMS-23-383-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c3/7229513/886bc3003d28/IJBMS-23-383-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c3/7229513/1a046d696ead/IJBMS-23-383-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40c3/7229513/c45859d23cb9/IJBMS-23-383-g007.jpg

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