Maeng Lisa Y, Milad Mohammed R
Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA, USA.
Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
Chronic Stress (Thousand Oaks). 2017 Jun 27;1:2470547017713297. doi: 10.1177/2470547017713297. eCollection 2017 Jan-Dec.
Post-traumatic stress disorder (PTSD) is a disabling psychiatric condition that can develop following a physical, psychological, or sexual trauma. Despite the growing body of literature examining the psychological and biological factors involved in PTSD psychopathology, specific biomarkers that may improve diagnosis and treatment of PTSD have yet to be identified and validated. This challenge may be attributed to the diverse array of symptoms that individuals with the disorder manifest. Examining the interrelated stress and fear systems allows for a more comprehensive study of these symptoms, and through this approach, which aligns with the research domain criteria (RDoC) framework, neural and psychophysiological measures of PTSD have emerged. In this review, we discuss PTSD neurobiology and treatment within the context of fear and stress network interactions and elucidate the advantages of using an RDoC approach to better understand PTSD with fear conditioning and extinction paradigms.
创伤后应激障碍（PTSD）是一种致残性精神疾病，可在身体、心理或性创伤后发生。尽管研究PTSD精神病理学中涉及的心理和生物学因素的文献越来越多，但可能改善PTSD诊断和治疗的特定生物标志物尚未得到识别和验证。这一挑战可能归因于该疾病患者表现出的各种症状。研究相互关联的应激和恐惧系统有助于对这些症状进行更全面的研究，通过这种与研究领域标准（RDoC）框架相一致的方法，PTSD的神经和心理生理测量方法已经出现。在这篇综述中，我们在恐惧和应激网络相互作用的背景下讨论PTSD神经生物学和治疗，并阐明使用RDoC方法通过恐惧条件化和消退范式更好地理解PTSD的优势。
