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Phase-separated protein dynamics are affected by fluorescent tag choice.

作者信息

Uebel Celja J, Phillips Carolyn M

机构信息

Department of Biological Sciences, University of Southern California, Los Angeles, California, United States of America.

出版信息

MicroPubl Biol. 2019;2019. Epub 2019 Aug 19.

PMID:32440657
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7241484/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25a7/7241484/76a9cbdca53f/nihms-1556215-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25a7/7241484/76a9cbdca53f/nihms-1556215-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25a7/7241484/76a9cbdca53f/nihms-1556215-f0001.jpg

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本文引用的文献

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Nat Struct Mol Biol. 2019 Mar;26(3):220-226. doi: 10.1038/s41594-019-0193-2. Epub 2019 Mar 4.
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Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates.研究液-液相分离和生物分子凝聚物的考虑因素和挑战。
Cell. 2019 Jan 24;176(3):419-434. doi: 10.1016/j.cell.2018.12.035.
3
Liquid phase condensation in cell physiology and disease.细胞生理学和疾病中的液相凝聚。
无序序列可以调节真菌的生长和细胞周期以适应特定温度。
Curr Biol. 2024 Aug 19;34(16):3722-3734.e7. doi: 10.1016/j.cub.2024.07.015. Epub 2024 Jul 31.
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Fluorescent protein tags affect the condensation properties of a phase-separating viral protein.荧光蛋白标签会影响一种发生相分离的病毒蛋白的凝聚特性。
Mol Biol Cell. 2024 Jul 1;35(7):ar100. doi: 10.1091/mbc.E24-01-0013. Epub 2024 May 29.
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Short disordered termini and proline-rich domain are major regulators of UBQLN1/2/4 phase separation.短的无序末端和脯氨酸丰富结构域是 UBQLN1/2/4 相分离的主要调节剂。
Biophys J. 2024 Jun 4;123(11):1449-1457. doi: 10.1016/j.bpj.2023.11.3401. Epub 2023 Nov 30.
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