Uebel Celja J, Manage Kevin I, Phillips Carolyn M
Department of Biological Sciences, University of Southern California, Los Angeles, California, USA.
MicroPubl Biol. 2021 Feb 22;2021. doi: 10.17912/micropub.biology.000374.
RNA interference is a widely conserved mechanism of gene regulation and silencing across eukaryotes. In , RNA silencing is coordinated through perinuclear nuage containing at least four granules: P granules, Z granules, foci, and SIMR foci. Embryonic localization of these granules is known for all except SIMR foci. Here we establish that SIMR foci first appear at the nuclear periphery in the P germline blastomere and become numerous and bright in the Z2 and Z3 progenitor germ cells. This timing coincides with the appearance or de-mixing of other germline granules, providing further evidence for coordinated germ granule reorganization.
RNA干扰是真核生物中广泛保守的基因调控和沉默机制。在[具体物种]中，RNA沉默通过至少包含四种颗粒的核周云进行协调：P颗粒、Z颗粒、[未明确的foci]和SIMR foci。除SIMR foci外，其他颗粒在胚胎中的定位均已明确。在此，我们证实SIMR foci首先出现在P生殖系卵裂球的核周，在Z2和Z3祖代生殖细胞中变得数量众多且明亮。这个时间与其他生殖系颗粒的出现或分离相吻合，为生殖颗粒的协调重组提供了进一步的证据。
