Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Med Microbiol Immunol. 2020 Aug;209(4):545-552. doi: 10.1007/s00430-020-00677-z. Epub 2020 May 21.
Tetraspanins are membrane organizing proteins that play a role in organizing the cell surface through the formation of subcellular domains consisting of tetraspanins and their partner proteins. These complexes are referred to as tetraspanin enriched microdomains (TEMs) or the tetraspanin web. The formation of TEMs allows for the regulation of a variety of cellular processes such as adhesion, migration, signaling, and cell fusion. Tetraspanin CD53 is a member of the tetraspanin superfamily expressed exclusively within the immune compartment. Amongst others, B cells, CD4 T cells, CD8 T cells, dendritic cells, macrophages, and natural killer cells have all been found to express high levels of this protein on their surface. Almost three decades ago it was reported that patients who lacked CD53 suffered from an increased susceptibility to pathogens resulting in the clinical manifestation of recurrent viral, bacterial, and fungal infections. This clearly suggests a vital and non-redundant role for CD53 in immune function. Yet, despite this striking finding, the specific functional roles of CD53 within the immune system have remained elusive. This review aims to provide a concise overview of the published literature concerning CD53 and reflect on the underappreciated role of this protein in immune cell regulation and function.
四跨膜蛋白是一种膜组织蛋白，通过形成由四跨膜蛋白及其伴侣蛋白组成的亚细胞域，在组织细胞表面方面发挥作用。这些复合物被称为富含四跨膜蛋白的微域（TEMs）或四跨膜蛋白网。TEM 的形成允许调节各种细胞过程，如粘附、迁移、信号转导和细胞融合。CD53 是四跨膜蛋白超家族的成员，仅在免疫区室中表达。除其他外，B 细胞、CD4 T 细胞、CD8 T 细胞、树突状细胞、巨噬细胞和自然杀伤细胞的表面都发现表达这种蛋白的高水平。大约三十年前有报道称，缺乏 CD53 的患者对病原体的易感性增加，导致反复发生病毒、细菌和真菌感染的临床表现。这清楚地表明 CD53 在免疫功能中具有重要且不可替代的作用。然而，尽管有这一惊人的发现，CD53 在免疫系统中的具体功能作用仍然难以捉摸。本综述旨在提供有关 CD53 的已发表文献的简明概述，并反思该蛋白在免疫细胞调节和功能中的被低估作用。
