Division of Pediatrics and Neonatal Critical Care, Paris Saclay University Hospital-APHP & Paris Saclay University, Paris, France.
Unit of Clinical Epidemiology, "Bambino Gesu" Children Hospital-IRCCS, Rome, Italy.
Eur J Pediatr. 2020 Aug;179(8):1271-1278. doi: 10.1007/s00431-020-03690-9. Epub 2020 May 22.
The outbreak of SARS-CoV-2 is the worst healthcare emergency of this century, and its impact on pediatrics and neonatology is still largely unknown. The European Society for Pediatric and Neonatal Intensive Care (ESPNIC) launched the EPICENTRE (ESPNIC Covid pEdiatric Neonatal Registry) international, multicenter, and multidisciplinary initiative to study the epidemiology, clinical course, and outcomes of pediatric and neonatal SARS-CoV-2 infections. EPICENTRE background and aims are presented together with protocol details. EPICENTRE is open to centers all over the world, and this will allow to provide a pragmatic picture of the epidemic, with a particular attention to pediatric and neonatal critical care issues.Conclusions: EPICENTRE will allow researchers to clarify the epidemiology, clinical presentation, and outcomes of pediatric and neonatal SARS-CoV-2 infection, refining its clinical management and hopefully providing new insights for clinicians. What is Known: • COVID19 is the new disease caused by SARS-CoV-2 infection and is spreading around the globe. • Majority of data available about SARS-CoV-2 infections originates from adult patients. What is New: • EPICENTRE is the first international, multicenter, multidisciplinary, meta-data driven, hospital-based, online, prospective cohort registry dedicated to neonatal and pediatric SARS-CoV-2 infections. • EPICENTRE will allow to understand epidemiology and physiopathology of COVID19.
SARS-CoV-2 的爆发是本世纪最严重的医疗保健紧急事件，其对儿科和新生儿学的影响在很大程度上尚不清楚。欧洲儿科和新生儿重症监护学会（ESPNIC）发起了 EPICENTRE（ESPNIC COVID-19 儿科新生儿登记处）国际多中心多学科倡议，以研究儿科和新生儿 SARS-CoV-2 感染的流行病学、临床过程和结局。本文介绍了 EPICENTRE 的背景和目的，并详细介绍了方案细节。EPICENTRE 向世界各地的中心开放，这将能够提供有关该流行病的实际情况，特别关注儿科和新生儿重症监护问题。结论：EPICENTRE 将使研究人员能够阐明儿科和新生儿 SARS-CoV-2 感染的流行病学、临床表现和结局，完善其临床管理，并为临床医生提供新的见解。已知情况：• COVID-19 是由 SARS-CoV-2 感染引起的新疾病，正在全球范围内传播。• 大多数关于 SARS-CoV-2 感染的数据来自成年患者。新情况：• EPICENTRE 是首个针对新生儿和儿科 SARS-CoV-2 感染的国际、多中心、多学科、基于元数据的、基于医院的、在线、前瞻性队列登记处。• EPICENTRE 将有助于了解 COVID-19 的流行病学和病理生理学。
