Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California.
Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California.
J Clin Endocrinol Metab. 2020 Oct 1;105(10):e3688-95. doi: 10.1210/clinem/dgz264.
Epidemiologic studies of polycystic ovary syndrome (PCOS) are limited, especially in populations where diagnostic resources are less available. In these settings, an accurate, low-cost screening tool would be invaluable.
To test the use of a simple questionnaire to identify women at increased risk for PCOS and androgen excess (AE) disorders.
Prospective cohort study from 2006-2010.
Community-based.
Women aged 14 to 45 years.
A screening telephone questionnaire consisting of 3 questions was tested, where participants were asked to self-assess the presence/absence of male-like hair and menstrual irregularity. Participants were then invited to undergo a direct examination, including completing a medical history and undergoing a modified Ferriman-Gallwey (mFG) hirsutism score, ovarian ultrasound, and measurement of circulating total and free testosterone, DHEAS, TSH, prolactin and 17-hydroxyprogesterone levels.
Accuracy of questionnaire in predicting PCOS, AE, and irregular menses.
Participants with self-assessed irregular menses and/or excess hair were labeled "Possible Androgen Excess (Poss-AE)" and those self-assessed with regular menses and no excess hair were labeled "Probable Non-Androgen Excess (Non-AE)." The study was completed in 206/298 (69%) of the Poss-AE and in 139/192 (73%) of the Non-AE. Of Poss-AE and Non-AE subjects, 82.5% and 15.8%, respextively, presented with PCOS. The calculated sensitivity, specificity, positive predictive value, and negative predictive value of the 3-question telephone survey to predict PCOS was 89%, 78%, 85%, and 83%, respectively.
A simple telephone questionnaire, based on self-assessment of body hair and menstrual status, can be used with a high predictive value to identify women at risk for AE disorders, including PCOS, and to detect healthy controls. This approach could be an important tool for needed epidemiologic studies.
多囊卵巢综合征（PCOS）的流行病学研究有限，尤其是在诊断资源较少的人群中。在这些环境下，准确且低成本的筛查工具将是非常有价值的。
测试使用简单问卷识别患有 PCOS 和雄激素过多（AE）障碍风险较高的女性的方法。
2006 年至 2010 年进行的前瞻性队列研究。
基于社区。
年龄在 14 至 45 岁的女性。
测试了由 3 个问题组成的筛查电话问卷，其中要求参与者自我评估是否存在男性型毛发和月经不规律。然后邀请参与者进行直接检查，包括完成病史记录和进行改良 Ferriman-Gallwey（mFG）多毛症评分、卵巢超声检查以及测量循环总睾酮和游离睾酮、DHEAS、TSH、催乳素和 17-羟孕酮水平。
问卷预测 PCOS、AE 和不规则月经的准确性。
自我评估月经不规律和/或毛发过多的参与者被标记为“可能存在雄激素过多（Poss-AE）”，自我评估月经规律且无多余毛发的参与者被标记为“可能不存在雄激素过多（Non-AE）”。在 206/298（69%）名 Poss-AE 和 139/192（73%）名 Non-AE 参与者中完成了研究。Poss-AE 和 Non-AE 组中，分别有 82.5%和 15.8%的人患有 PCOS。基于电话调查的 3 个问题来预测 PCOS 的灵敏度、特异性、阳性预测值和阴性预测值分别为 89%、78%、85%和 83%。
基于自我评估身体毛发和月经状况的简单电话问卷，可以高预测值识别患有 AE 障碍（包括 PCOS）风险的女性，并检测健康对照者。这种方法可能是进行必要的流行病学研究的重要工具。
