Molecular Biology Department, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel 4070, Switzerland.
Cancer Cell. 2020 Jul 13;38(1):31-43. doi: 10.1016/j.ccell.2020.04.006. Epub 2020 May 21.
Functional genomics describes a field of biology that uses a range of approaches for assessing gene function with high-throughput molecular, genetic, and cellular technologies. The near limitless potential for applying these concepts to study the activities of all genetic loci has completely upended how today's cancer biologists tackle drug target discovery. We provide an overview of contemporary functional genomics platforms, highlighting areas of distinction and complementarity across technologies, so as to aid in the development or interpretation of cancer-focused screening efforts.
功能基因组学描述了生物学的一个领域，该领域使用一系列方法，通过高通量的分子、遗传和细胞技术来评估基因功能。将这些概念应用于研究所有遗传基因座的活性的潜力几乎是无限的，这完全改变了当今癌症生物学家发现药物靶点的方式。我们提供了当代功能基因组学平台的概述，强调了不同技术之间的区别和互补性，以帮助癌症相关筛选工作的开展或解释。
