Chen Cong, Zhu Xue-Ying, Zhou Kun, Li Dong, Lin Qian
Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing.
Shandong University of Traditional Chinese Medicine, Shandong, Jinan.
Medicine (Baltimore). 2020 May;99(20):e20135. doi: 10.1097/MD.0000000000020135.
Although patients with coronary artery disease (CAD) rely increasingly upon percutaneous coronary intervention (PCI), this therapy causes subsequent the complications of myocardial injury. Acupuncture safely protects the heart from ischemic injury; however, the efficacy of acupuncture for periprocedural myocardial injury after PCI remains unclear.
Seven databases in English and Chinese including PubMed, Web of Science, Cochrane Library, Embase, Chinese Biomedical Literature Database, Chinese National Knowledge Infrastructure, and Wanfang Database will be searched. Randomized controlled trials (RCTs) that use acupuncture to treat PCI-related myocardial injury in patients with CAD, regardless of blinding. The crossover randomized trials will be included, but only the pre-crossover data will be analyzed to avoid carryover effects. We will exclude non-RCTs, qualitative studies, uncontrolled clinical trials, and laboratory studies. The measurement of concentration of cardiac troponin (T or I) and MB isoenzyme of creatine kinase will be used as primary outcome. Postprocedural cardiac function and the major adverse cardiac/cerebrovascular event rate will be assessed as secondary outcome. Relevant data were collected independently by 2 reviewers and the third reviewer was responsible for resolving discrepancies through discussion. The Review Manager V.5.3.3 s will be used to perform the data synthesis and subgroup analysis.
This systematic review and meta-analysis would provide convincing evidence of various types of acupuncture that specifically focuses on cardioprotective effect of acupuncture on PCI-related myocardial injury.
Open Science Framework (OSF) registries (osf.io/n2e6t) with the registration DOI: 10.17605/OSF.IO/79H2E.
尽管冠状动脉疾病（CAD）患者越来越依赖经皮冠状动脉介入治疗（PCI），但这种治疗会引发心肌损伤的后续并发症。针刺可安全地保护心脏免受缺血性损伤；然而，针刺对PCI术后围手术期心肌损伤的疗效仍不明确。
将检索包括PubMed、Web of Science、Cochrane图书馆、Embase、中国生物医学文献数据库、中国知网和万方数据库在内的7个中英文数据库。使用针刺治疗CAD患者PCI相关心肌损伤的随机对照试验（RCT），无论是否采用盲法。将纳入交叉随机试验，但仅分析交叉前的数据以避免残留效应。我们将排除非RCT、定性研究、非对照临床试验和实验室研究。将心肌肌钙蛋白（T或I）浓度和肌酸激酶MB同工酶的测量作为主要结局。术后心功能和主要不良心脑血管事件发生率将作为次要结局进行评估。相关数据由2名研究者独立收集，第三名研究者负责通过讨论解决分歧。将使用Review Manager V.5.3.3进行数据合成和亚组分析。
本系统评价和荟萃分析将为各种类型的针刺提供令人信服的证据，特别关注针刺对PCI相关心肌损伤的心脏保护作用。
开放科学框架（OSF）注册库（osf.io/n2e6t），注册DOI：10.17605/OSF.IO/79H2E。
