Miggiano Riccardo, Rizzi Menico, Ferraris Davide M
Department of Pharmaceutical Sciences, University of Piemonte Orientale, Via Bovio 6, 28100 Novara, Italy.
Pathogens. 2020 May 18;9(5):385. doi: 10.3390/pathogens9050385.
Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis (MTB) and it represents a persistent public health threat for a number of complex biological and sociological reasons. According to the most recent Global Tuberculosis Report (2019) edited by the World Health Organization (WHO), TB is considered the ninth cause of death worldwide and the leading cause of mortality by a single infectious agent, with the highest rate of infections and death toll rate mostly concentrated in developing and low-income countries. We present here the editorial section to the Special Issue entitled "Mycobacterium tuberculosis Pathogenesis, Infection Prevention and Treatment" that includes 7 research articles and a review. The scientific contributions included in the Special Issue mainly focus on the characterization of MTB strains emerging in TB endemic countries as well as on multiple mechanisms adopted by the bacteria to resist and to adapt to antitubercular therapies.
结核病（TB）是由结核分枝杆菌（MTB）引起的一种传染病，由于多种复杂的生物学和社会学原因，它对公共卫生构成持续威胁。根据世界卫生组织（WHO）编辑的最新《全球结核病报告》（2019年），结核病被认为是全球第九大致死原因，也是单一感染源导致死亡的主要原因，感染率和死亡率最高的情况大多集中在发展中国家和低收入国家。在此，我们展示了题为“结核分枝杆菌的发病机制、感染预防与治疗”的特刊社论部分，该特刊包含7篇研究文章和1篇综述。该特刊中的科学贡献主要集中在结核病流行国家出现的MTB菌株的特征描述，以及细菌为抵抗和适应抗结核治疗所采用的多种机制。
