Industrial Park of Advanced Technologies, ASEPE Company, Tabriz, 5364196795, Iran.
Photonics and Nanocrystal Research Lab (PNRL), Faculty of Electrical and Computer Engineering, University of Tabriz, Tabriz, 5166614761, Iran.
Sci Rep. 2022 Nov 19;12(1):19934. doi: 10.1038/s41598-022-24540-8.
In this paper, we synthesized Ag/ZnO composite colloidal nanoparticles and the surface of nanoparticles was improved by amodiaquine ligand. The synthesized nanoparticles were characterized using the XRD diffraction pattern, FT-IR Spectroscopy, TEM image, and UV-Vis spectroscopy. The antibacterial, antifungal, and antiviral effects of the synthesized colloid were examined on E.coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Enterococcus hirae bacteria, and Candida Albicans and form spore aspergillus fungi, also influenza, herpes simplex, and covid 19 viruses. The results indicate more than 7 log removal of the bacteria, fungi, and viruses by synthesized colloid with a concentration of 15 μg/L (Ag)/50 µg/ml (ZnO). This removal for covid 19 virus is from 3.2 × 10 numbers to 21 viruses within 30 s. Also, irritation and toxicity tests of the synthesized colloid show harmless effects on human cells and tissues. These colloidal nanoparticles were used as mouthwash solution and their clinical tests were done on 500 people infected by the coronavirus. The results indicate that by washing their mouth and nose three times on day all patients got healthy at different times depending on the depth of the disease. Almost all people with no signs of infection and using this solution as a mouthwash didn't infect by the virus during the study.
在本文中，我们合成了 Ag/ZnO 复合胶体纳米粒子，并通过阿莫地喹配体改善了纳米粒子的表面。通过 XRD 衍射图、FT-IR 光谱、TEM 图像和 UV-Vis 光谱对合成的纳米粒子进行了表征。我们研究了合成胶体对 E.coli、金黄色葡萄球菌、铜绿假单胞菌和肠球菌的抗菌、抗真菌和抗病毒作用，以及白色念珠菌和曲霉孢子真菌，还有流感、单纯疱疹和新冠病毒。结果表明，合成胶体在浓度为 15μg/L（Ag）/50μg/ml（ZnO）时，可去除超过 7 个对数的细菌、真菌和病毒。对于新冠病毒，去除率为 3.2×10 数量级至 21 个病毒，仅需 30 秒。此外，合成胶体的刺激和毒性试验表明对人体细胞和组织无害。这些胶体纳米粒子被用作漱口液，并在 500 名感染冠状病毒的患者中进行了临床测试。结果表明，通过每天三次漱口和洗鼻，所有患者在不同时间都恢复了健康，具体时间取决于疾病的严重程度。几乎所有没有感染迹象的人在研究期间都没有感染病毒，而且使用这种溶液作为漱口液。
