Department of Medical Education, Ditmanson Medical Foundation, Chia-Yi Christian Hospital, Chia-Yi 60002, Taiwan.
Department of Family Medicine, Ditmanson Medical Foundation, Chia-Yi Christian Hospital, Chia-Yi 60002, Taiwan.
Int J Environ Res Public Health. 2020 May 20;17(10):3592. doi: 10.3390/ijerph17103592.
Physical diseases, such as infection, and emotional distress are associated with herpes zoster (HZ). However, the relationship between adhesive capsulitis of the shoulder (ACoS) and HZ remains unknown.
This study investigated the risk of HZ development in patients with ACoS.
We analyzed the Longitudinal Health Insurance Database, a subset of 1 million beneficiaries from the National Health Insurance Research Database. Patients newly diagnosed with ACoS during the 2000-2012 period were the case group. Each patient with ACoS was matched to a control, according to age and index year, through frequency matching. HZ was the primary event in this study.
A total of 60,478 patients were included and each group contained 30,239 patients. The risk of HZ infection in the case cohort was 1.28 times that of the control cohort. ACoS increased the risk of HZ infection in each age group, particularly among patients aged younger than 50 [adjusted hazard ratio (aHR) = 1.52, 95% confidence interval (CI): 1.31-1.75]. Relative to the control group, the hazard ratio of HZ for male patients (aHR = 1.40, 95% CI: 1.26-1.55) in the case group was higher than that for female patients (aHR = 1.22, 95% CI: 1.13-1.32). Conclusion Patients with ACoS have a higher risk of HZ development, particularly among those aged younger than 50 years. The effect of ACoS on HZ development among young adults requires attention.
感染等躯体疾病和情绪困扰与带状疱疹（HZ）相关。然而，肩粘连性囊炎（ACoS）与 HZ 之间的关系尚不清楚。
本研究调查了 ACoS 患者发生 HZ 的风险。
我们分析了纵向健康保险数据库，这是国家健康保险研究数据库的一个子集，包含 100 万受益人的数据。2000-2012 年期间新诊断为 ACoS 的患者为病例组。通过频率匹配，每位 ACoS 患者都与一名对照者按照年龄和索引年份相匹配。本研究中 HZ 是主要事件。
共纳入 60478 例患者，每组 30239 例。病例组 HZ 感染的风险是对照组的 1.28 倍。ACoS 增加了各年龄段 HZ 感染的风险，尤其是 50 岁以下的患者（校正后的危险比[aHR] = 1.52，95%置信区间[CI]：1.31-1.75）。与对照组相比，病例组中男性患者（aHR = 1.40，95%CI：1.26-1.55）发生 HZ 的风险比高于女性患者（aHR = 1.22，95%CI：1.13-1.32）。结论：ACoS 患者发生 HZ 的风险较高，尤其是 50 岁以下的患者。ACoS 对年轻成年人 HZ 发病的影响值得关注。
