[用免疫荧光法对胸腺肌样细胞的研究]

[Study of the myoid cells of the thymus by the immunofluorescent method].

作者信息

Beletskaia L V, Gnezditskaia E V

出版信息

Arkh Anat Gistol Embriol. 1977 Feb;72(2):5-10.

Abstract

Muscular proteins were found in the cytoplasm of myoid cells of the thymus in all investigated species (chicken, mouse, rat, guinea pig, rabbit, cattle, human) by the method of immunofluorescence using the human serum containing antibodies to antigens of muscular fibres of striated muscles and fluorescent antibodies to human immunoglobulins. Under study were the characteristic features of the content and localization of the myoid antigen in the sarcolytes of the thymus of animals and man. The obtained data show a permanent presence of muscular antigens in the internal medium of the thymus and speak in favour of their possible participation, in addition to other heteroorganic antigens of the thymus, in the formation of natural immunological tolerance to the proper antigens of the organism in the process of differentiation of thymocytes.

摘要

采用免疫荧光法，使用含有针对横纹肌肌纤维抗原的抗体的人血清以及针对人免疫球蛋白的荧光抗体，在所有被研究的物种（鸡、小鼠、大鼠、豚鼠、兔、牛、人）的胸腺类肌细胞的细胞质中均发现了肌肉蛋白。研究了动物和人类胸腺肌浆中类肌抗原的含量和定位特征。所获数据表明胸腺内部介质中持续存在肌肉抗原，这表明除胸腺的其他异种有机抗原外，它们可能在胸腺细胞分化过程中参与机体自身抗原的天然免疫耐受性形成。