重症肌无力。针对横纹肌中一种酸溶性抗原的抗体。
Myasthenia gravis. Antibodies to an acid-soluble antigen in striated muscle.
作者信息
Aarli J A
出版信息
Clin Exp Immunol. 1972 Mar;10(3):453-61.
Abstract
Citric acid extracts were prepared from human skeletal and heart muscle. Antibodies of γG-class to components of this extract were demonstrated in twelve out of fifty-three sera from patients with myasthenia gravis. The antigen is poorly soluble in saline but is converted into a soluble form by diluted citric acid. Apparently, the antigen is also present in small amounts in saline extracts of thymus. No cross-reactivity with other organs was demonstrated.
摘要
从人体骨骼肌和心肌中制备了柠檬酸提取物。在53例重症肌无力患者的血清中，有12例检测出针对该提取物成分的γG类抗体。该抗原在盐溶液中溶解性较差，但用稀释的柠檬酸可将其转化为可溶形式。显然，胸腺的盐溶液提取物中也含有少量该抗原。未显示与其他器官有交叉反应。
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