Gnezditskaia E V, Beletskaia L V
Biull Eksp Biol Med. 1978 Nov;86(11):616-20.
The indirect immunofluorescence method showed that decreased (in comparison with myoid cells of adult human thymus) content of muscle antigens in the myoid elements of the embryonic organ caused a greater secretory activity of these elements at the early embryogenesis. Due to increased secretory activity of the myoid cells internal medium of the embryonic thymus contained more antigens common to the muscle tissue than the adult human thymus. The fact that during the ontogenesis the functional activity of the myoid cells correlated with the rate of lymphoid tissue formation favours a suggestion that heteroorganic antigens provide the thymus lymphocytes with information concerning the autoantigen structure necessary to induce natural immunological tolerance.
间接免疫荧光法显示，与成人胸腺的肌样细胞相比，胚胎器官肌样成分中肌肉抗原含量降低，这导致这些成分在胚胎发育早期具有更高的分泌活性。由于肌样细胞分泌活性增加，胚胎胸腺的内部介质中所含的肌肉组织共同抗原比成人胸腺更多。在个体发育过程中，肌样细胞的功能活性与淋巴组织形成速率相关，这一事实支持了这样一种观点，即异种器官抗原为胸腺淋巴细胞提供了有关诱导天然免疫耐受所需自身抗原结构的信息。
