中老年休闲时间体力活动与全脑淀粉样蛋白负荷：动脉粥样硬化风险社区（ARIC）-PET 研究。

Mid- and Late-Life Leisure-Time Physical Activity and Global Brain Amyloid Burden: The Atherosclerosis Risk in Communities (ARIC)-PET Study.

机构信息

Division of General Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.

Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

出版信息

J Alzheimers Dis. 2020;76(1):139-147. doi: 10.3233/JAD-200152.

DOI:10.3233/JAD-200152

PMID:32444546

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8011955/

Abstract

BACKGROUND

Physical activity (PA) may slow the development of dementia by reducing the accumulation of amyloid.

OBJECTIVE

We tested the hypothesis that higher levels of leisure-time PA in mid- or late-life were associated with lower brain amyloid burden in late-life among 326 non-demented participants from the Atherosclerosis Risk in Communities Study of brain florbetapir positron emission tomography (ARIC-PET) ancillary.

METHODS

Self-reported PA was quantified using a past-year recall, interviewer-administered questionnaire in mid-life (1987-1989, aged 45-64 years) and late-life (2011-2013, aged 67-89 years). Continuous PA estimates were classified as 1) any leisure-time PA participation (yes/no); 2) meeting the 2018 United States' PA guidelines (yes/no); and 3) per 1 standard deviation (SD) higher metabolic equivalent of task (MET) minutes per week (MET·min·wk-1). A brain magnetic resonance imaging scan with Florbetapir PET was performed in late-life. Adjusted odds ratios (OR) of elevated amyloid burden, defined as a global cortical standardized uptake value ratio (>1.2), compared to no elevated amyloid burden were estimated according to PA measures.

RESULTS

Among the 326 participants (mean age: 76 years, 42% male, 41% Black), 52% had elevated brain amyloid burden. Mid-life leisure-time PA did not show a statistically significant lower odds of elevated late-life amyloid burden (OR = 0.71, 95% CI: 0.43-1.18). A 1 SD (970 MET. min. wk-1) higher PA level in mid-life was also not significantly associated withelevated amyloid burden (OR = 0.89, 95% CI: 0.69-1.15). Similar estimates were observed for meeting versus not meeting PA guidelines in both mid- and late-life.

CONCLUSION

Self-reported higher mid- and late-life leisure-time PA were not significantly associated with lower amyloid burden. Data show a trend of an association, which is, however, imprecise, suggesting replication in larger studies.

摘要

背景

身体活动（PA）可通过减少淀粉样蛋白的积累来减缓痴呆的发展。

目的

我们检验了以下假设，即在 326 名来自社区动脉粥样硬化风险研究（ARIC-PET）辅助研究的无痴呆参与者中，中晚年较高水平的休闲时间身体活动与晚年较低的脑淀粉样蛋白负担有关。

方法

使用过去一年的回忆，在中年（1987-1989 年，年龄 45-64 岁）和晚年（2011-2013 年，年龄 67-89 岁）通过访谈者管理的问卷来量化自我报告的 PA。连续的 PA 估计分为 1）任何休闲时间 PA 参与（是/否）；2）符合 2018 年美国 PA 指南（是/否）；和 3）每 1 个标准差（SD）更高的代谢当量任务（MET）分钟/周（MET·min·wk-1）。在晚年进行了脑磁共振成像扫描和 Florbetapir PET。根据 PA 测量，估计了与无升高淀粉样蛋白负担相比，升高的淀粉样蛋白负担（定义为皮质全局标准化摄取比值（>1.2））的调整比值比（OR）。

结果

在 326 名参与者（平均年龄：76 岁，42%为男性，41%为黑人）中，有 52%的人有升高的脑淀粉样蛋白负担。中年休闲时间 PA 与晚年升高的淀粉样蛋白负担的可能性没有统计学上的显著降低（OR=0.71，95%CI：0.43-1.18）。中年时 PA 水平每增加 1 SD（970 MET·min·wk-1）也与升高的淀粉样蛋白负担没有显著相关（OR=0.89，95%CI：0.69-1.15）。在中晚年，符合与不符合 PA 指南的情况也有类似的估计。