Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Rd, CNR #3051, Atlanta, GA, 30322, USA.
Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Health System, Los Angeles, CA, USA.
BMC Cardiovasc Disord. 2022 Apr 26;22(1):196. doi: 10.1186/s12872-022-02643-4.
To evaluate the association of physical activity (PA) with atrial fibrillation (AF) incidence in an elderly population.
We studied 5166 participants of the Atherosclerosis Risk in Communities cohort examined in 2011-2013 free of AF. Self-reported PA was evaluated with a validated questionnaire. Weekly minutes of leisure-time moderate to vigorous physical activity (MVPA) were calculated and categorized using the 2018 Physical Activity Guidelines for Americans (no activity [0 min/week], low [> 0- < 150 min/week], adequate [150- < 300 min/week], high [≥ 300 min/week]). Incident AF through 2019 was ascertained from hospital discharges and death certificates. Cox models were used to calculate hazard ratios (HR) and 95% confidence intervals (CI) for AF by levels of physical activity adjusting for potential confounders.
The mean (SD) age for the sample was 75 (5) years (59% female, 22% Black). During a mean (SD) follow-up time of 6.3 (2.0) years, 703 AF events were identified. The association of MVPA with AF incidence showed a U-shaped relationship. Compared to those not engaging in MVPA, individuals with low MVPA had a 23% lower hazard of AF (HR = 0.77; 95% CI 0.61, 0.96), while those with adequate MVPA had a 14% lower hazard (HR 0.86; 95% CI 0.69, 1.06). High levels of MVPA were not associated with AF risk (HR 0.97; 95% CI 0.78, 1.20).
This study suggests that being involved in low to moderate levels of MVPA is associated with lower AF risk, with no evidence of increased risk of AF in those with higher levels of MVPA.
评估体力活动（PA）与老年人群心房颤动（AF）发病率的相关性。
我们研究了 2011-2013 年无 AF 的社区动脉粥样硬化风险（ARIC）队列中的 5166 名参与者。使用经过验证的问卷评估自我报告的 PA。每周的休闲时间中等到剧烈体力活动（MVPA）分钟数通过 2018 年美国体力活动指南进行计算和分类（无活动[0 分钟/周]、低[>0-<150 分钟/周]、充足[150-<300 分钟/周]、高[≥300 分钟/周]）。通过医院出院和死亡证明确定 2019 年发生的 AF 事件。Cox 模型用于计算调整潜在混杂因素后不同体力活动水平的 AF 风险比（HR）和 95%置信区间（CI）。
样本的平均（SD）年龄为 75（5）岁（59%为女性，22%为黑人）。在平均（SD）6.3（2.0）年的随访期间，确定了 703 例 AF 事件。MVPA 与 AF 发病率的相关性呈 U 型关系。与不进行 MVPA 的人相比，MVPA 水平低的人患 AF 的风险降低了 23%（HR=0.77；95%CI 0.61,0.96），而 MVPA 水平充足的人患 AF 的风险降低了 14%（HR 0.86；95%CI 0.69,1.06）。高水平的 MVPA 与 AF 风险无关（HR 0.97；95%CI 0.78,1.20）。
这项研究表明，参与低至中等水平的 MVPA 与较低的 AF 风险相关，而在 MVPA 水平较高的人群中，没有 AF 风险增加的证据。
