Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Halal Research Center of IRI, FDA, Tehran, Iran.
Biofactors. 2020 Jul;46(4):514-530. doi: 10.1002/biof.1634. Epub 2020 May 22.
As an evolutionarily conserved pathway, Hippo signaling pathway impacts different pathology and physiology processes such as wound healing, tissue repair/size and regeneration. When some components of Hippo signaling dysregulated, it affects cancer cells proliferation. Moreover, the relation Hippo pathway with other signaling including Wnt, TGFβ, Notch, and EGFR signaling leaves effect on the proliferation of cancer cells. Utilizing a number of therapeutic approaches, such as siRNAs and long noncoding RNA (lncRNA) to prevent cancer cells through the targeting of Hippo pathways, can provide new insights into cancer target therapy. The purpose of present review, first of all, is to demonstrate the importance of Hippo signaling and its relation with other signaling pathways in cancer. It also tries to demonstrate targeting Hippo signaling progress in cancer therapy.
作为一个进化上保守的途径，Hippo 信号通路影响不同的病理学和生理学过程，如伤口愈合、组织修复/大小和再生。当 Hippo 信号的某些成分失调时，它会影响癌细胞的增殖。此外，Hippo 途径与其他信号通路（包括 Wnt、TGFβ、Notch 和 EGFR 信号通路）的关系对癌细胞的增殖也有影响。利用多种治疗方法，如 siRNA 和长链非编码 RNA（lncRNA），通过靶向 Hippo 通路来预防癌细胞，可以为癌症的靶向治疗提供新的见解。本综述的目的首先是展示 Hippo 信号及其与癌症中其他信号通路的关系的重要性。它还试图展示 Hippo 信号在癌症治疗中的靶向进展。
