Faculty of Chemistry, Biology Department, Laboratories F-225, National Autonomous University of Mexico, CDMX, 04510, Mexico.
Faculty of Chemistry, Biology Department, Laboratories F-315, National Autonomous University of Mexico, CDMX, 04510, Mexico; Posgrado en Ciencias Biológicas, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México, 04510, Mexico.
Virus Res. 2020 Sep;286:198016. doi: 10.1016/j.virusres.2020.198016. Epub 2020 May 20.
Although it has been established that persistent infection with high risk human papillomavirus (HR-HPV) is the main cause in the development of cervical cancer, the HR-HPV infection is also related with the cause of a significant fraction of other human malignancies from the mucosal squamous epithelial such as anus, vagina, vulva, penis and oropharynx. HR-HPV infection induces cell proliferation, cell death evasion and genomic instability resulting in cell transformation, due to HPV proteins, which target and modify the function of differents cell molecules and organelles, such as mitochondria. Mitochondria are essential in the production of the cellular energy by oxidative phosphorylation (OXPHOS), in the metabolism of nucleotides, aminoacids (aa), and fatty acids, even in the regulation of cell death processes such as apoptosis or mitophagy. Thus, mitochondria have a significant role in the HPV-related cancer development. This review focuses on the role of HPV and mitochondria in HPV-related cancer development, and treatments associated to mitochondrial apoptosis.
虽然已经确定高危型人乳头瘤病毒（HR-HPV）的持续感染是宫颈癌发展的主要原因，但 HR-HPV 感染也与肛门、阴道、外阴、阴茎和口咽等黏膜鳞状上皮的其他人类恶性肿瘤的部分病因有关。HR-HPV 感染通过 HPV 蛋白诱导细胞增殖、逃避细胞死亡和基因组不稳定，导致细胞转化，这些蛋白靶向并改变不同细胞分子和细胞器的功能，如线粒体。线粒体在通过氧化磷酸化（OXPHOS）产生细胞能量、核苷酸、氨基酸（aa）和脂肪酸代谢、甚至在调节细胞死亡过程（如细胞凋亡或线粒体自噬）中都具有重要作用。因此，线粒体在 HPV 相关癌症的发展中具有重要作用。本综述重点介绍 HPV 和线粒体在 HPV 相关癌症发展中的作用，以及与线粒体凋亡相关的治疗方法。
