Mesenchymal Stem Cell Laboratory, School of Medical Sciences, Faculty of Health Sciences, The University of Adelaide, Adelaide, SA, Australia; South Australian Health and Medical Research Institute, Adelaide, SA, Australia.
Mesenchymal Stem Cell Laboratory, School of Medical Sciences, Faculty of Health Sciences, The University of Adelaide, Adelaide, SA, Australia; South Australian Health and Medical Research Institute, Adelaide, SA, Australia.
Bone. 2020 Aug;137:115440. doi: 10.1016/j.bone.2020.115440. Epub 2020 May 20.
There is mounting evidence in the literature that mesenchymal stromal/stem cell (MSC) like populations derived from different tissues, undergo epigenetic changes during aging, leading to compromised connective tissue integrity and function. This body of work has linked the biological aging of MSC to changes in their epigenetic signatures affecting growth, lifespan, self-renewal and multi-potential, due to deregulation of processes such as cellular senescence, oxidative stress, DNA damage, telomere shortening and DNA damage. This review addresses recent findings examining DNA methylation, histone modifications and miRNA changes in aging MSC populations. Moreover, we explore how epigenetic factors alter cellular pathways and associated biological networks, contributing to the MSC aging phenotype. Finally we discuss the crucial areas requiring a greater understanding of these processes, in order to piece together a global picture of the changing epigenetic landscape in MSC during aging.
越来越多的文献证据表明，来源于不同组织的间充质基质/干细胞（MSC）样群体在衰老过程中会经历表观遗传变化，导致结缔组织完整性和功能受损。这些研究将 MSC 的生物学衰老与它们的表观遗传特征变化联系起来，这些变化影响生长、寿命、自我更新和多潜能性，这是由于细胞衰老、氧化应激、DNA 损伤、端粒缩短和 DNA 损伤等过程的失调。这篇综述探讨了最近关于衰老 MSC 群体中 DNA 甲基化、组蛋白修饰和 miRNA 变化的发现。此外，我们还探讨了表观遗传因素如何改变细胞途径和相关的生物学网络，从而导致 MSC 衰老表型。最后，我们讨论了需要更深入了解这些过程的关键领域，以便拼凑出 MSC 在衰老过程中不断变化的表观遗传景观的全貌。
