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Measurement of underivatized propranolol enantiomers in serum using a cellulose-tris(3,5-dimethylphenylcarbamate) high-performance liquid chromatographic (HPLC) chiral stationary phase.

作者信息

Straka R J, Lalonde R L, Wainer I W

机构信息

Department of Clinical Pharmacy, University of Tennessee, Memphis 38163.

出版信息

Pharm Res. 1988 Mar;5(3):187-9. doi: 10.1023/a:1015921124857.

DOI:10.1023/a:1015921124857
PMID:3244632
Abstract

A commercially available high-performance liquid chromatographic (HPLC) chiral stationary phase (HPLC-CSP) has been used to measure serum levels of d- and l-propranolol. The HPLC-CSP is based upon cellulose-tris(3,5-dimethylcarbamate) and is able to stereochemically resolve d- and l-propranolol without precolumn derivatization using a mobile phase composed of hexane:2-propranol:N,N-dimethyloctylamine (92:8:0.01, v/v/v). Under these conditions the observed stereochemical resolution (alpha) of the two enantiomers was alpha = 2.2. A subject's concentration-time curve of the two isomers was determined following the ingestion of 160 mg racemic propranolol.

摘要

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引用本文的文献

1
Nonlinear accumulation of propranolol enantiomers.普萘洛尔对映体的非线性蓄积
Br J Clin Pharmacol. 1988 Jul;26(1):100-2. doi: 10.1111/j.1365-2125.1988.tb03371.x.

本文引用的文献

1
The biological properties of the optical isomers of propranolol and their effects on cardiac arrhythmias.心得安光学异构体的生物学特性及其对心律失常的影响。
Br J Pharmacol. 1968 Sep;34(1):43-55. doi: 10.1111/j.1476-5381.1968.tb07949.x.
2
Simultaneous determination of d- and l-propranolol in human plasma by high-performance liquid chromatography.高效液相色谱法同时测定人血浆中d-和l-普萘洛尔
J Chromatogr. 1980 Nov 14;221(1):109-17. doi: 10.1016/s0378-4347(00)81012-9.
3
Stereospecific assay for (-)- and (+)-propranolol in human and dog plasma.
人血浆和犬血浆中（-）-和（+）-普萘洛尔的立体特异性测定。
J Pharmacol Exp Ther. 1980 Dec;215(3):643-8.
4
Separation and quantitation of (R)- and (S)- propranolol as their diastereomeric derivatives in human plasma by reversed-phase ion-pair chromatography.采用反相离子对色谱法在人血浆中分离并定量测定（R）-和（S）-普萘洛尔的非对映体衍生物。
Acta Pharm Suec. 1982;19(1):11-24.
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The direct enantiomeric determination of (-)- and (+)-propranolol in human serum by high-performance liquid chromatography on a chiral stationary phase.
J Chromatogr. 1984 Mar 9;306:405-11. doi: 10.1016/s0378-4347(00)80907-x.
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Separation of the enantiomers of intact sulfate conjugates of adrenergic drugs by high-performance liquid chromatography after chiral derivatization.
J Chromatogr. 1985 May 31;341(1):213-6. doi: 10.1016/s0378-4347(00)84031-1.
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Food effects on propranolol systemic and oral clearance: support for a blood flow hypothesis.食物对普萘洛尔全身清除率和口服清除率的影响：对血流假说的支持。
Clin Pharmacol Ther. 1986 Oct;40(4):408-14. doi: 10.1038/clpt.1986.198.
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Propranolol pharmacokinetics and pharmacodynamics after single doses and at steady-state.
Eur J Clin Pharmacol. 1987;33(3):315-8. doi: 10.1007/BF00637569.