Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA; Institute of Biomedical Engineering, Bogazici University, Istanbul 34684, Turkey.
Institute of Biomedical Engineering, Bogazici University, Istanbul 34684, Turkey.
Neurosci Lett. 2020 Aug 10;733:135076. doi: 10.1016/j.neulet.2020.135076. Epub 2020 May 22.
It is crucial to reveal the variability between patients with epilepsy and healthy subjects to elucidate the underpinnings of the disease pathology. Herein, we assessed the inter-subject variability between patients with temporal lobe epilepsy (TLE) and healthy subjects in terms of estimating the functional connectivity using resting-state functional magnetic resonance (rs-fMRI) scans. According to inter-subject variability results between healthy and TLE population, the latter showed more variability mainly in frontoparietal control, default mode, dorsal/ventral attention, visual and somatomotor networks in line with the broad seizure onset and propagation pathway. As a result of 17-Network parcellation, a significant attenuation is observed in functional connectivity, mostly in bilateral frontoparietal control, somatomotor, default mode and ventral attention networks associated with the functional impairment in attention, long/short term memory, executive functioning. The results are in favor of the argument that the functional disruption in TLE spreads throughout the cortex beyond the temporal lobe with an implication of greater diversity in the TLE population.
揭示癫痫患者与健康受试者之间的变异性对于阐明疾病病理基础至关重要。在此，我们使用静息态功能磁共振(rs-fMRI)扫描评估了颞叶癫痫（TLE）患者和健康受试者之间的个体间变异性，以估计功能连接。根据健康人群和 TLE 人群之间的个体间变异性结果，后者主要在前顶叶控制、默认模式、背/腹注意、视觉和躯体运动网络中表现出更大的变异性，与广泛的发作起始和传播途径一致。由于 17 网络分割，功能连接明显减弱，主要在双侧顶叶控制、躯体运动、默认模式和腹侧注意网络中，与注意力、长/短期记忆、执行功能的功能障碍相关。这些结果支持这样一种观点，即 TLE 中的功能障碍不仅在颞叶内，而且在整个皮层中扩散，这意味着 TLE 人群的多样性更大。
