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近无柄金丝桃中金丝桃素P的脂肪生成抑制活性

Adipogenesis Inhibitory Activity of Hypersampsone P from Hypericum subsessile.

作者信息

Zhou Hui-Min, Ye Yan-Song, Jiang Na-Na, Mu Rong-Fang, Wang Qian, Hu Jing, Liu Xia, Qin Wan-Ying, Xu Gang, Xiong Wen-Yong

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan, People's Republic of China.

University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.

出版信息

Nat Prod Bioprospect. 2020 Jun;10(3):163-170. doi: 10.1007/s13659-020-00245-1. Epub 2020 May 23.

DOI:10.1007/s13659-020-00245-1
PMID:32447748
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7253573/
Abstract

Adamantane polycyclic polyprenylated acylphloroglucinols (PPAPs) with caged architecture, a special class of hybrid natural products, is specifically rich in the plant family Guttiferae, especially Hypericum or Garcinia genus. Hypersampsone P is one of Adamantane PPAPs compounds extracted from Hypericum subsessile. Here we have chosen, screened ten PPAPs and identified one of them showed an activity in inhibiting of adipocytes differentiation. Particularly, the compound, hypersampsone P, blunted the adipocyte differentiation dose-dependently. Moreover, hypersampsone P down-regulated the expressions of several key regulators for adipogenesis, including PPARγ and FABP4. The treatment of cells at the early stage of adipogenesis by hypersampsone P induced the greatest blunting of adipocyte differentiation and the effect might be involved in the LKB1-AMPK signaling pathway.

摘要

具有笼状结构的金刚烷多环多异戊烯基酰基间苯三酚（PPAPs）是一类特殊的杂合天然产物，在藤黄科植物中特别丰富，尤其是金丝桃属或藤黄属植物。超桑普森酮P是从近无柄金丝桃中提取的金刚烷PPAPs化合物之一。在这里，我们选择、筛选了十种PPAPs，并鉴定出其中一种具有抑制脂肪细胞分化的活性。特别地，化合物超桑普森酮P剂量依赖性地抑制脂肪细胞分化。此外，超桑普森酮P下调了包括PPARγ和FABP4在内的几种脂肪生成关键调节因子的表达。在脂肪生成早期用超桑普森酮P处理细胞可诱导最大程度的脂肪细胞分化抑制，其作用可能涉及LKB1-AMPK信号通路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e8/7253573/6ca6ac73ab8d/13659_2020_245_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e8/7253573/1b0bacee9c8c/13659_2020_245_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e8/7253573/3d3f8c07a29a/13659_2020_245_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e8/7253573/39cb8d661150/13659_2020_245_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e8/7253573/7772ca4f8890/13659_2020_245_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e8/7253573/6ca6ac73ab8d/13659_2020_245_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e8/7253573/1b0bacee9c8c/13659_2020_245_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e8/7253573/3d3f8c07a29a/13659_2020_245_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e8/7253573/39cb8d661150/13659_2020_245_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e8/7253573/7772ca4f8890/13659_2020_245_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e8/7253573/6ca6ac73ab8d/13659_2020_245_Fig5_HTML.jpg

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