弓形虫感染与自杀的关联：系统评价和荟萃分析。
Association of T. gondii infection with suicide: a systematic review and meta-analysis.
机构信息
Students Research Committee, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Research Center for Health Sciences, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran.
出版信息
BMC Public Health. 2020 May 24;20(1):766. doi: 10.1186/s12889-020-08898-w.
BACKGROUND
Findings on the association between Toxoplasma gondii (T. gondii) infection and suicide are contradictory. This paper aimed to resolve this uncertainty by conducting a meta-analysis.
METHODS
We found the relevant studies using keywords include "Toxoplasmosis" and "Suicide" and the related synonyms in international databases such as ISI, Medline, and Scopus. The eligible studies were included in the meta-analysis phase. The random effect approach was applied to combine the results.
RESULTS
Out Of 150 initial studies, 15 were included in the meta-analysis. Odds of suicide in people with T. gondii infection was 43% (OR: 1.43, 95%CI; 1.15 to 1.78) higher than those without this infection. The test for publication bias was not statistically significant, which indicates the absence of likely publication bias.
CONCLUSION
This study confirms that T. gondii infection is a potential risk factor for suicide. To reduce cases of suicide attributable to T. gondii infection, it is recommended to implement some measures to prevent and control the transmission of the disease.
背景
弓形虫（Toxoplasma gondii，T. gondii）感染与自杀之间的关联的研究结果存在矛盾。本研究旨在通过荟萃分析解决这一不确定性。
方法
我们使用国际数据库（如 ISI、Medline 和 Scopus）中的关键词“弓形虫病”和“自杀”以及相关同义词来查找相关研究。将符合条件的研究纳入荟萃分析阶段。采用随机效应方法合并结果。
结果
在最初的 150 项研究中，有 15 项纳入荟萃分析。感染弓形虫的人自杀的几率比未感染的人高 43%（OR：1.43，95%CI；1.15 至 1.78）。发表偏倚检验无统计学意义，表明可能不存在发表偏倚。
结论
本研究证实，弓形虫感染是自杀的一个潜在危险因素。为了减少归因于弓形虫感染的自杀病例，建议采取一些预防和控制疾病传播的措施。
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