Xiangya Nursing School, Central South University, Changsha, Hunan, China.
Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, Hunan, China.
Adv Clin Chem. 2020;97:117-140. doi: 10.1016/bs.acc.2019.12.004. Epub 2020 Feb 8.
Cervical cancer is a common gynecologic malignant tumor with high mortality. HOX transcript antisense RNA (HOTAIR), a trans-acting long non-coding RNA (lncRNA) containing six exons in humans, is transcribed from the antisense strand of homeobox gene C cluster. This lncRNA serves as a modular scaffold for gene silencing and protein ubiquitination. In patients with cervical cancer, elevated HOTAIR levels are significantly associated with poor prognosis. HOTAIR plays an oncogenic role in cervical cancer by promoting cell proliferation, migration, invasion and autophagy, inhibiting cell apoptosis, stimulating angiogenesis, accelerating cell cycle progression, and inducing epithelial-mesenchymal transition. Moreover, blockade of HOTAIR by artesunate or propofol shows promise for further development of this lncRNA as a potential therapeutic target in cervical cancer. In this review, we summarized the latest advances regarding the role of HOTAIR in cervical cancer with an emphasis on its diagnostic and prognostic values.
宫颈癌是一种常见的妇科恶性肿瘤，死亡率较高。HOX 转录反义 RNA（HOTAIR）是一种人类反义链上含有六个外显子的反式作用长非编码 RNA（lncRNA），由同源盒基因 C 簇的反义链转录而来。这种 lncRNA 作为基因沉默和蛋白质泛素化的模块化支架。在宫颈癌患者中，HOTAIR 水平升高与预后不良显著相关。HOTAIR 通过促进细胞增殖、迁移、侵袭和自噬，抑制细胞凋亡，刺激血管生成，加速细胞周期进程，诱导上皮-间充质转化，在宫颈癌中发挥致癌作用。此外，青蒿琥酯或异丙酚阻断 HOTAIR 显示出进一步开发这种 lncRNA 作为宫颈癌潜在治疗靶点的前景。在这篇综述中，我们总结了 HOTAIR 在宫颈癌中的作用的最新进展，重点介绍了其诊断和预后价值。
