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神秘病毒:对新型冠状病毒 2019-nCoV 的行为和治疗方法的综述。

Mysterious Virus: A Review on Behavior and Treatment Approaches of the Novel Coronavirus, 2019-nCoV.

机构信息

Plant Virology Research Center, College of Agriculture, Shiraz University, Shiraz, Iran.

Department of Medical Microbiology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.

出版信息

Arch Med Res. 2020 Jul;51(5):375-383. doi: 10.1016/j.arcmed.2020.04.022. Epub 2020 May 6.

Abstract

At the end of the year 2019, the novel coronavirus (2019-nCoV) was spreading in Wuhan, China, and the outbreak process has a high speed. It was recognized as a pandemic by the World Health Organization (WHO) on 11 March 2020. Coronaviruses are enveloped and single-stranded RNA that have several families including Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS). The pathogenesis mechanism and disease outcomes of SARS and MERS are now clear to some extent, but little information is available for 2019-nCoV. This newly identified corona virus infection represents flu-like symptoms, but usually the first symptoms are fever and dry cough. There has been no specific treatment against 2019-nCoV up to now, and physicians only apply supportive therapy. In the present article, we made an attempt to review the behavior of the virus around the world, epidemiology, a pathway for influx into the host cells, clinical presentation, as well as the treatments currently in use and future approaches; nitazoxanide may be our dream drug. We hope that this review has a positive impact on public knowledge for helping to deal with the 2019-nCoV and move one step forward toward its treatment in the near future.

摘要

2019 年年末,新型冠状病毒(2019-nCoV)在中国武汉传播,其爆发过程呈高速态势。世界卫生组织(WHO)于 2020 年 3 月 11 日宣布将其认定为大流行。冠状病毒为包膜、单链 RNA,包括严重急性呼吸综合征(SARS)和中东呼吸综合征(MERS)在内有多个家族。SARS 和 MERS 的发病机制和疾病结果目前已在一定程度上明确,但对于 2019-nCoV 几乎没有信息。这种新发现的冠状病毒感染表现为流感样症状,但通常首发症状为发热和干咳。到目前为止,还没有针对 2019-nCoV 的特效治疗方法,医生只能应用支持疗法。在本文中,我们尝试回顾了该病毒在全球范围内的行为、流行病学、进入宿主细胞的途径、临床表现以及目前使用的和未来的治疗方法;硝唑尼特可能是我们的理想药物。我们希望这篇综述能对公众知识产生积极影响,帮助人们应对 2019-nCoV,并在不久的将来朝着其治疗方向迈出一步。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b95b/7200354/aa6828125e58/gr1_lrg.jpg

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