Department of Communication, Collaborator Member of the Health Outcomes & Behavior Program, Moffitt Cancer Center, the University of South Florida, Tampa, FL, USA.
Geisinger Health System, Danville, PA, USA.
Am J Mens Health. 2020 May-Jun;14(3):1557988320924932. doi: 10.1177/1557988320924932.
Men are at risk for developing hereditary cancers such as breast, prostate, pancreatic, and melanoma due to a pathogenic germline variant in either the or gene. The purpose of this study was to identify and provide practical advice for men managing their BRCA-related cancer risks based on men's real-life experiences. Semistructured interviews were conducted with 25 men who either tested positive for a pathogenic variant in gene or who had an immediate family member who had tested positive for a pathogenic variant in . A thematic analysis of the interview transcripts was completed utilizing the constant comparison method. Qualitative analysis produced three categories of participant advice for men who recently learned of their hereditary cancer risk. Specifically, participants advised the following: (a) know the basics, (b) engage in the family narrative, and (c) advocate for yourself. Results showed the need for men to know and understand their BRCA cancer risks and communicate that genetic risk information to their family members and practitioners. In particular, the findings stress the importance of addressing men's risks and medical management from a family-focused approach. Overall, because men are historically undereducated about their BRCA-related cancer risks, this practical advice serves as a first step for men managing BRCA-related cancer risks and may ultimately assist them in making preventive and screening health behaviors.
男性由于 或 基因中的致病变异体而面临罹患遗传性癌症（如乳腺癌、前列腺癌、胰腺癌和黑色素瘤）的风险。本研究的目的是根据男性的真实生活经验，确定并为管理 BRCA 相关癌症风险的男性提供实用建议。对 25 名经基因检测呈致病变异体阳性或直系亲属经基因检测呈致病变异体阳性的男性进行了半结构化访谈。利用恒定性比较法对访谈记录进行了主题分析。定性分析得出了男性最近了解到其遗传性癌症风险后的三条建议类别。具体而言，参与者建议：（a）了解基础知识，（b）参与家庭叙述，以及（c）为自己争取权益。研究结果表明，男性需要了解和理解他们的 BRCA 癌症风险，并将遗传风险信息传达给他们的家庭成员和医生。特别是，研究结果强调了从以家庭为中心的角度来解决男性风险和医疗管理的重要性。总体而言，由于男性对其 BRCA 相关癌症风险的教育历来不足，因此这些实用建议为男性管理 BRCA 相关癌症风险提供了第一步，最终可能有助于他们采取预防性和筛查性的健康行为。
