Castelli Vanessa, Melani Francesco, Ferri Claudio, d'Angelo Michele, Catanesi Mariano, Grassi Davide, Benedetti Elisabetta, Giordano Antonio, Cimini Annamaria, Desideri Giovambattista
Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
Menarini Industrie Farmaceutiche Riunite srl, Florence, Italy.
J Cell Biochem. 2020 Dec;121(12):4862-4869. doi: 10.1002/jcb.29722. Epub 2020 May 25.
Oxidative stress is considered the common effector of the cascade of degenerative events in many neurological conditions. Thus, in this paper we tested different nutraceuticals in H O in vitro model to understand if could represent an adjuvant treatment for neurological diseases. In this study, nutraceuticals bacopa, lycopene, astaxanthin, and vitamin B12 were used alone or in combination in human neuronal differentiated SH-SY5Y cells upon hydrogen peroxide-induced injury and neuroprotective, neuronal death pathways were analyzed. The nutraceuticals analyzed were able to protect H O cytotoxic effects, through increasing cell viability and proteins involved in neuroprotection pathways and restoring proteins involved in cell death pathways. On this basis, it is possible to propose the use of these compounds as dietary supplement for the prevention or as adjuvant to the only symptomatic treatments so far available for neurodegenerative diseases.
氧化应激被认为是许多神经疾病中一系列退行性事件的共同效应器。因此，在本文中，我们在过氧化氢体外模型中测试了不同的营养保健品，以了解它们是否可以作为神经疾病的辅助治疗方法。在这项研究中，在过氧化氢诱导损伤的情况下，营养保健品印度醋栗、番茄红素、虾青素和维生素B12单独或联合用于人神经元分化的SH-SY5Y细胞，并分析了神经保护、神经元死亡途径。所分析的营养保健品能够通过提高细胞活力以及参与神经保护途径的蛋白质，并恢复参与细胞死亡途径的蛋白质，来保护细胞免受过氧化氢的细胞毒性作用。在此基础上，有可能建议使用这些化合物作为饮食补充剂来预防神经退行性疾病，或作为目前仅有的对症治疗的辅助手段。
