KAGAMI Project, National Institute of Biomedical Innovation, Health and Nutrition (NIBIOHN), Japan; Reverse Translational Research Project, Center for Rare Disease Research, National Institute of Biomedical Innovation, Health and Nutrition (NIBIOHN), Japan; Department of Nephrology, Osaka University Graduate School of Medicine, Japan.
KAGAMI Project, National Institute of Biomedical Innovation, Health and Nutrition (NIBIOHN), Japan; Reverse Translational Research Project, Center for Rare Disease Research, National Institute of Biomedical Innovation, Health and Nutrition (NIBIOHN), Japan; Department of Nephrology, Osaka University Graduate School of Medicine, Japan.
Biochim Biophys Acta Proteins Proteom. 2020 Sep;1868(9):140449. doi: 10.1016/j.bbapap.2020.140449. Epub 2020 May 22.
d-Serine, a long-term undetected enantiomer of serine, is now showing its potential as a biomarker for kidney diseases. The intra-body dynamics of d-serine, currently defined by blood levels and urinary excretion dynamics, are useful for a comprehensive assessment of kidney function and disease activity. Thus, widespread adoption of d-serine as a biomarker can resolve the long-standing clinical challenge of the early detection and prognostic prediction of kidney diseases. Accuracy and reliability of the measurements are particularly important because these measurements will affect treatment decisions and thus impact the patient's emotional state and quality of life. Accordingly, this review focuses on current clinical challenges in kidney diseases and the potential for monitoring of d-serine to overcome these issues, and discuss the requirements of accurate quantification.
d-丝氨酸是丝氨酸的一种长期未被发现的对映异构体，现在正显示出其作为肾脏疾病生物标志物的潜力。目前，通过血液水平和尿液排泄动力学来定义体内 d-丝氨酸的动态变化，可用于全面评估肾脏功能和疾病活动。因此，广泛采用 d-丝氨酸作为生物标志物可以解决肾脏疾病早期检测和预后预测的长期临床挑战。测量的准确性和可靠性尤为重要，因为这些测量结果将影响治疗决策，从而影响患者的情绪状态和生活质量。因此，本综述重点讨论了肾脏疾病目前面临的临床挑战，以及监测 d-丝氨酸克服这些问题的潜力，并讨论了准确量化的要求。
