Su Li-Da, Xu Fang-Xiao, Wang Xin-Tai, Cai Xin-Yu, Shen Ying
Neuroscience Care Unit, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China.
Department of Physiology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Neuroscience. 2021 May 10;462:320-327. doi: 10.1016/j.neuroscience.2020.05.028. Epub 2020 May 23.
The cerebellum has long been conceptualized to control motor learning and motor coordination. However, increasing evidence suggests its roles in cognition and emotion behaviors. In particular, the cerebellum has been recognized as one of key brain regions affected in autism spectrum disorder (ASD). To better understand the contribution of the cerebellum in ASD pathogenesis, we here discuss recent behavioral, genetic, and molecular studies from the human and mouse models. In addition, we raise several questions that need to be investigated in future studies from the point view of cerebellar dysfunction, cerebro-cerebellar connectivity and ASD.
长期以来，小脑被认为是控制运动学习和运动协调的器官。然而，越来越多的证据表明它在认知和情感行为中也发挥着作用。特别是，小脑已被公认为是自闭症谱系障碍（ASD）中受影响的关键脑区之一。为了更好地理解小脑在ASD发病机制中的作用，我们在此讨论来自人类和小鼠模型的最新行为学、遗传学和分子学研究。此外，我们从小脑功能障碍、脑-小脑连接和ASD的角度提出了几个需要在未来研究中进行调查的问题。
