Canbolat Fadime, Kul Aykut, Özdemir Murat, Atik Uğur, Aydin Ahmet, Özden S Tuncel, Tarhan K Nevzat
Üsküdar University, Advanced Toxicology Analysis Laboratory, İstanbul, Turkey.
Yeditepe University, Faculty of Pharmacy, Department of Toxicology, İstanbul, Turkey.
Turk J Pharm Sci. 2017 Dec;14(3):294-303. doi: 10.4274/tjps.50470. Epub 2017 Nov 20.
To determine the substance abuse profiles of patients treated a Drug Addiction Research, Treatment, and Education Center (AMATEM) in association with the percentage of substance use distribution and multiple substance use in their urine samples. For this, we retrospectively evaluated the urine sample analysis reports of 600 male and female patients aged 13 to 65 years who were treated at the AMATEM unit of İstanbul Neuropsychiatry Hospital between January 1, 2015, and December 12, 2015.
The urine samples were sent to Üsküdar University Advanced Toxicology Analysis Laboratory and were analyzed using a UPLC tandem mass spectrometer (UPLC-MS/MS). To determine the substance use profiles of the patients applying to AMATEM, statistical assessment was performed on the analysis reports of the patients.
When the analysis reports of the 600 urine samples were examined, 293 patients were identified to have used addictive substances. The substances most frequently detected in the urine samples were respectively: cannabis, alcohol, morphine, cocaine, synthetic cannabinoids, 3,4-Methylenedioxymethamphetamine, and amphetamine.
The findings in our study resemble the rates of cannabis use by the young population throughout the world. Our results show differences to the literature regarding the consumption of synthetic cannabinoids because the variety of synthetic cannabinoids change rapidly around the world each year.
确定在药物成瘾研究、治疗与教育中心(AMATEM)接受治疗的患者的药物滥用情况,以及其尿液样本中药物使用分布百分比和多种药物使用情况。为此,我们回顾性评估了2015年1月1日至2015年12月12日期间在伊斯坦布尔神经精神病医院AMATEM科室接受治疗的600名年龄在13至65岁之间的男性和女性患者的尿液样本分析报告。
尿液样本被送往于斯屈达尔大学高级毒理学分析实验室,并用超高效液相色谱串联质谱仪(UPLC-MS/MS)进行分析。为确定申请AMATEM的患者的药物使用情况,对患者的分析报告进行了统计评估。
在检查600份尿液样本的分析报告时,发现293名患者使用过成瘾性物质。尿液样本中最常检测到的物质分别为:大麻、酒精、吗啡、可卡因、合成大麻素、3,4-亚甲基二氧甲基苯丙胺和苯丙胺。
我们研究中的发现与全球年轻人群的大麻使用率相似。我们的结果在合成大麻素消费方面与文献有所不同,因为每年全球合成大麻素的种类变化迅速。