Ramu Sathiya, Murali Anita, Jayaraman Anbu
M. S. Ramaiah University of Applied Sciences, Faculty of Pharmacy, Department of Pharmacology, Bangalore, Karnataka, India.
Turk J Pharm Sci. 2019 Dec;16(4):466-475. doi: 10.4274/tjps.galenos.2018.68442. Epub 2019 Nov 11.
The present study was conducted to identify the phytoconstituents present in different extracts of and to assess the toxicity of its ethanol extract.
Successive solvent extraction and total ethanol extraction of were performed and preliminary phytochemical screening was carried out. The acute toxicity of ethanol extract of (ESW) was studied. The subchronic toxicity of ESW was tested with doses of 100, 200, and 400 mg/kg. The animals were observed for changes in body weight and food and water intake. At the end of the study, the relative weights of vital organs were noted, followed by histopathological examinations. Various hematological and biochemical estimations were also carried out.
Phytochemical screening of revealed the presence of alkaloids, carbohydrates, glycosides, phenolic compounds, and tannins. ESW did not induce any mortality or pre-terminal death in the acute toxicity study. There were no significant differences in body weight, relative weight of vital organs (except the brain), or food or water intake compared to the control group. The histopathological examination showed normal architecture, suggesting absence of pathological lesions. Hematological and biochemical parameters were also comparable to those of the control group except for reductions in glucose and cholesterol levels, which are postulated to be beneficial.
The presence of various phytoconstituents in S. wightii is evidence that it could be a potential source for treating different ailments. No significant toxic effects were observed after treatment with ESW. Thus, it is proposed to be safe and can be recommended for long-term treatment.
开展本研究以鉴定[植物名称]不同提取物中存在的植物成分，并评估其乙醇提取物的毒性。
对[植物名称]进行连续溶剂萃取和全乙醇萃取，并进行初步植物化学筛选。研究了[植物名称]乙醇提取物（ESW）的急性毒性。用100、200和400mg/kg的剂量测试ESW的亚慢性毒性。观察动物体重、食物和水摄入量的变化。在研究结束时，记录重要器官的相对重量，随后进行组织病理学检查。还进行了各种血液学和生化评估。
[植物名称]的植物化学筛选显示存在生物碱、碳水化合物、糖苷、酚类化合物和单宁。在急性毒性研究中，ESW未引起任何死亡或濒死。与对照组相比，体重、重要器官的相对重量（除大脑外）、食物或水摄入量均无显著差异。组织病理学检查显示结构正常，表明无病理病变。血液学和生化参数也与对照组相当，只是葡萄糖和胆固醇水平降低，推测这是有益的。
怀特[植物名称]中存在多种植物成分，证明它可能是治疗不同疾病的潜在来源。用ESW治疗后未观察到明显的毒性作用。因此，建议其是安全的，可推荐用于长期治疗。
