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提取物激活Nrf2/HO-1通路可抑制脂多糖诱导的氧化应激及…… （原文此处不完整）

Activation of the Nrf2/HO-1 Pathway by Extract Suppresses LPS-Induced Oxidative Stress and .

作者信息

Lim Dong-Woo, Choi Hee-Jin, Park Sun-Dong, Kim Hyuck, Yu Ga-Ram, Kim Jai-Eun, Park Won-Hwan

机构信息

Department of Pathology, College of Korean Medicine, Dongguk University, Goyang-si 10326, Republic of Korea.

Department of Korean Medical Science, College of Korean Medicine, Pusan National University, Yangsan-si 50612, Republic of Korea.

出版信息

Evid Based Complement Alternat Med. 2020 May 3;2020:2837853. doi: 10.1155/2020/2837853. eCollection 2020.

DOI:10.1155/2020/2837853
PMID:32454852
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7218974/
Abstract

Despite its deleterious effects on living cells, oxidative stress plays essential roles in normal physiological processes and provides signaling molecules for cell growth, differentiation, and inflammation. Macrophages are equipped with antioxidant mechanisms to cope with intracellular ROS produced during immune response, and Nrf2 (NF-E2-related factor 2)/HO-1 (heme oxygenase-1) pathway is an attractive target due to its protective effect against ROS-induced cell damage in inflamed macrophages. We investigated the effects of ethanol extract of (AVEE) on lipopolysaccharide- (LPS-) stimulated inflammatory responses generated via the Nrf2/HO-1 signaling pathway in murine peritoneal macrophages and RAW 264.7 cells. AVEE was found to suppress the NF-B signaling pathway, thus, to reduce proinflammatory cytokine, nitric oxide, and prostaglandin levels in peritoneal macrophages and Raw 264.7 cells treated with LPS, and to enhance HO-1 expression by activating Nrf2 signaling. Furthermore, these anti-inflammatory effects of AVEE were diminished when cells were pretreated with SnPP (a HO-1 inhibitor). HPLC analysis revealed AVEE contained quercetin, a possible activator of the Nrf2/HO-1 pathway. These results show ethanol extract exerts anti-inflammatory effects by activating the Nrf2/HO-1 pathway in LPS-stimulated macrophages.

摘要

尽管氧化应激对活细胞有有害影响，但它在正常生理过程中发挥着重要作用，并为细胞生长、分化和炎症提供信号分子。巨噬细胞具备抗氧化机制来应对免疫反应过程中产生的细胞内活性氧（ROS），而核因子E2相关因子2（Nrf2）/血红素加氧酶-1（HO-1）途径因其对炎症巨噬细胞中ROS诱导的细胞损伤具有保护作用而成为一个有吸引力的靶点。我们研究了[具体植物名称]乙醇提取物（AVEE）对小鼠腹腔巨噬细胞和RAW 264.7细胞中通过Nrf2/HO-1信号通路产生的脂多糖（LPS）刺激的炎症反应的影响。发现AVEE可抑制核因子κB（NF-κB）信号通路，从而降低LPS处理的腹腔巨噬细胞和Raw 264.7细胞中促炎细胞因子、一氧化氮和前列腺素水平，并通过激活Nrf2信号增强HO-1表达。此外，当细胞用SnPP（一种HO-1抑制剂）预处理时，AVEE的这些抗炎作用减弱。高效液相色谱分析显示AVEE含有槲皮素，它可能是Nrf2/HO-1途径的激活剂。这些结果表明[具体植物名称]乙醇提取物通过在LPS刺激的巨噬细胞中激活Nrf2/HO-1途径发挥抗炎作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7545/7218974/619734b1caf3/ECAM2020-2837853.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7545/7218974/f2a85b0c17e3/ECAM2020-2837853.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7545/7218974/a664ec265f14/ECAM2020-2837853.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7545/7218974/d051445b6b3e/ECAM2020-2837853.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7545/7218974/681086d544a5/ECAM2020-2837853.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7545/7218974/03e7e5fcabd1/ECAM2020-2837853.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7545/7218974/39aff870cead/ECAM2020-2837853.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7545/7218974/619734b1caf3/ECAM2020-2837853.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7545/7218974/f2a85b0c17e3/ECAM2020-2837853.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7545/7218974/a664ec265f14/ECAM2020-2837853.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7545/7218974/d051445b6b3e/ECAM2020-2837853.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7545/7218974/681086d544a5/ECAM2020-2837853.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7545/7218974/03e7e5fcabd1/ECAM2020-2837853.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7545/7218974/39aff870cead/ECAM2020-2837853.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7545/7218974/619734b1caf3/ECAM2020-2837853.007.jpg

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