Department of Aerospace Engineering, Universiti Putra Malaysia, Serdang 43400, Malaysia.
Aerospace Malaysia Reaserch Center (AMRC), Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
Comput Math Methods Med. 2020 May 4;2020:9163085. doi: 10.1155/2020/9163085. eCollection 2020.
This study investigated the impact of paravalvular leakage (PVL) in relation to the different valve openings of the transcatheter aortic valve implantation (TAVI) valve using the fluid structure interaction (FSI) approach. Limited studies were found on the subject of FSI with regards to TAVI-PVL condition, which involves both fluid and structural responses in coupling interaction. Hence, further FSI simulation with the two-way coupling method is implemented to investigate the effects of hemodynamics blood flow along the patient-specific aorta model subjected to the interrelationship between PVL and the different valve openings using the established FSI software ANSYS 16.1. A 3D patient-specific aorta model is constructed using MIMICS software. The TAVI valve identical to Edward SAPIEN XT 26 (Edwards Lifesciences, Irvine, California), at different Geometrical Orifice Areas (GOAs), is implanted into the patient's aortic annulus. The leaflet opening of the TAVI valve is drawn according to severity of GOA opening represented in terms of 100%, 80%, 60%, and 40% opening, respectively. The result proved that the smallest percentage of GOA opening produced the highest possibility of PVL, increased the recirculatory flow proximally to the inner wall of the ascending aorta, and produced lower backflow velocity streamlines through the side area of PVL region. Overall, 40% GOA produced 89.17% increment of maximum velocity magnitude, 19.97% of pressure drop, 65.70% of maximum WSS magnitude, and a decrement of 33.62% total displacement magnitude with respect to the 100% GOA.
本研究采用流固耦合（FSI）方法，研究了瓣周漏（PVL）与经导管主动脉瓣植入（TAVI）瓣膜不同开口之间的关系。关于 TAVI-PVL 情况下的 FSI，仅有有限的研究涉及涉及流体和结构响应的耦合相互作用。因此，进一步采用双向耦合方法进行 FSI 模拟，以研究血流动力学沿特定于患者的主动脉模型的影响，该模型受到 PVL 与不同瓣膜开口之间相互关系的影响，使用已建立的 FSI 软件 ANSYS 16.1。使用 MIMICS 软件构建了 3D 特定于患者的主动脉模型。将与爱德华 SAPIEN XT 26（爱德华生命科学公司，加利福尼亚州欧文）相同的 TAVI 瓣膜植入患者的主动脉瓣环中，具有不同的几何孔口面积（GOA）。根据 GOA 开口的严重程度，绘制 TAVI 瓣膜的瓣叶开口，分别代表 100％、80％、60％和 40％的开口。结果证明，GOA 开口的最小百分比产生了最高的 PVL 可能性，增加了升主动脉内壁附近的再循环流，并通过 PVL 区域的侧面积产生了较低的回流速度流线。总体而言，40％GOA 产生了 89.17％的最大速度幅度增量、19.97％的压降、65.70％的最大 WSS 幅度和 33.62％的总位移幅度相对于 100％GOA。
