• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

不同精油配方的抗菌活性。

Antimicrobial Activity of Different Essential Oil Formulations.

机构信息

Department of Laboratory Medicine, University of Pécs, Medical School, 7624 Pécs, Ifjúság u. 13., Hungary.

János Szentágothai Research Center, University of Pécs, Ifjúság u. 20., 7624 Pécs, Hungary.

出版信息

Molecules. 2020 May 21;25(10):2390. doi: 10.3390/molecules25102390.

DOI:10.3390/molecules25102390
PMID:32455592
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7287661/
Abstract

The extreme lipophilicity of essential oils (EOs) impedes the measurement of their biological actions in an aqueous environment. We formulated oil in water type Pickering EO nanoemulsions (AEP) with surface-modified Stöber silica nanoparticles (20 nm) as the stabilizing agent. The antimicrobial activity of AEP and its effects on mature biofilms were compared with those of Tween 80 stabilized emulsion (AET) and ethanolic solution (AEE) of the EO. The antimicrobial activity was evaluated by using the minimum inhibitory concentrations (MIC) and minimum effective concentrations (MEC) of the compounds. On planktonic bacterial and fungal cells beside growth inhibition, colony formation (CFU/mL), metabolic activity, viability, intracellular ATP/total protein (ATP/TP), along with reactive oxygen species (ROS) were also studied. EO nanoemulsion (AEP) showed significantly higher antimicrobial activity than AET and AEE. EO nanoemulsions (AEP) generated superoxide anion and peroxides-related oxidative stress, which might be the underlying mode of action of the EO. Unilamellar liposomes, as a cellular model, were used to examine the delivery efficacy of the EO of our tested formulations. We could demonstrate higher effectiveness of AEP in the EO components' donation compared to AET and AEE. Our data suggest the superiority of the AEP formulation against microbial infections.

摘要

精油（EOs）的极端疏水性阻碍了其在水环境中生物活性的测量。我们用表面改性的斯托贝二氧化硅纳米颗粒（20nm）作为稳定剂，制备了油包水型 Pickering EO 纳米乳（AEP）。我们比较了 AEP 的抗菌活性及其对成熟生物膜的影响，与 Tween 80 稳定乳液（AET）和 EO 的乙醇溶液（AEE）的效果进行了比较。通过最小抑菌浓度（MIC）和最低有效浓度（MEC）来评估化合物的抗菌活性。除了抑制浮游细菌和真菌细胞的生长外，还研究了菌落形成（CFU/mL）、代谢活性、活力、细胞内 ATP/总蛋白（ATP/TP）以及活性氧（ROS）。与 AET 和 AEE 相比，EO 纳米乳（AEP）表现出显著更高的抗菌活性。EO 纳米乳（AEP）产生了超氧阴离子和过氧化物相关的氧化应激，这可能是 EO 的作用机制。我们使用作为细胞模型的单层脂质体来检查我们测试配方的 EO 的递药效果。与 AET 和 AEE 相比，我们可以证明 AEP 在 EO 成分的供体中具有更高的功效。我们的数据表明，AEP 配方在对抗微生物感染方面具有优越性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8df/7287661/2f1fdce792a0/molecules-25-02390-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8df/7287661/b9be6fed5605/molecules-25-02390-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8df/7287661/31344bc4ce98/molecules-25-02390-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8df/7287661/97072c97de76/molecules-25-02390-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8df/7287661/82d4a972254b/molecules-25-02390-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8df/7287661/433eeaff2d86/molecules-25-02390-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8df/7287661/515acf4305ba/molecules-25-02390-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8df/7287661/bcb12c5f28a3/molecules-25-02390-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8df/7287661/5302325657fb/molecules-25-02390-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8df/7287661/15844d7a0080/molecules-25-02390-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8df/7287661/2f1fdce792a0/molecules-25-02390-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8df/7287661/b9be6fed5605/molecules-25-02390-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8df/7287661/31344bc4ce98/molecules-25-02390-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8df/7287661/97072c97de76/molecules-25-02390-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8df/7287661/82d4a972254b/molecules-25-02390-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8df/7287661/433eeaff2d86/molecules-25-02390-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8df/7287661/515acf4305ba/molecules-25-02390-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8df/7287661/bcb12c5f28a3/molecules-25-02390-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8df/7287661/5302325657fb/molecules-25-02390-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8df/7287661/15844d7a0080/molecules-25-02390-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8df/7287661/2f1fdce792a0/molecules-25-02390-g010.jpg

相似文献

1
Antimicrobial Activity of Different Essential Oil Formulations.不同精油配方的抗菌活性。
Molecules. 2020 May 21;25(10):2390. doi: 10.3390/molecules25102390.
2
Antimicrobial Activity of Chamomile Essential Oil: Effect of Different Formulations.香菊精油的抗菌活性：不同配方的影响。
Molecules. 2019 Nov 26;24(23):4321. doi: 10.3390/molecules24234321.
3
Physical and antimicrobial properties of cinnamon bark oil co-nanoemulsified by lauric arginate and Tween 80.月桂酰精氨酸酯和吐温80共同纳米乳化的肉桂皮油的物理和抗菌性能
Int J Food Microbiol. 2016 Sep 16;233:52-59. doi: 10.1016/j.ijfoodmicro.2016.06.016. Epub 2016 Jun 16.
4
Antibacterial, anti-biofilm and anti-quorum sensing activities of Artemisia dracunculus essential oil (EO): a study against Salmonella enterica serovar Typhimurium and Staphylococcus aureus.龙蒿精油（EO）的抗菌、抗生物膜和抗群体感应活性：对肠炎沙门氏菌血清型 Typhimurium 和金黄色葡萄球菌的研究。
Arch Microbiol. 2021 May;203(4):1529-1537. doi: 10.1007/s00203-020-02138-w. Epub 2021 Jan 5.
5
Chemical Composition and Antimicrobial Activity of Artemisia herba-alba and Origanum majorana Essential Oils from Morocco.摩洛哥小白蒿和马郁兰精油的化学成分和抗菌活性。
Molecules. 2019 Nov 6;24(22):4021. doi: 10.3390/molecules24224021.
6
Antimicrobial and antibiofilm activities of nanoemulsions containing Eucalyptus globulus oil against Pseudomonas aeruginosa and Candida spp.纳米乳剂中含有蓝桉油对铜绿假单胞菌和念珠菌属的抗菌和抗生物膜活性。
Microb Pathog. 2017 Nov;112:230-242. doi: 10.1016/j.micpath.2017.09.062. Epub 2017 Sep 29.
7
Action of essential oils from Brazilian native and exotic medicinal species on oral biofilms.巴西本土和外来药用植物精油对口腔生物膜的作用。
BMC Complement Altern Med. 2014 Nov 18;14:451. doi: 10.1186/1472-6882-14-451.
8
Phytochemical Profile and In Vitro Antioxidant, Antimicrobial, Vital Physiological Enzymes Inhibitory and Cytotoxic Effects of Leaves Essential Oil from Palestine.巴勒斯坦叶精油的植物化学特征及体外抗氧化、抗菌、重要生理酶抑制和细胞毒性作用
Molecules. 2021 May 10;26(9):2831. doi: 10.3390/molecules26092831.
9
Chemical composition of hydrodistilled essential oil of Artemisia incana (L.) Druce and antimicrobial activity against foodborne microorganisms.水蒸馏法提取艾蒿精油的化学成分及对食源性病原体的抗菌活性。
Chem Biodivers. 2009 Dec;6(12):2302-10. doi: 10.1002/cbdv.200800317.
10
Anti- Activity of Selected Essential Oils Detected by TLC-Direct Bioautography and Biofilm Inhibition.TLC-直接生物自显影和生物膜抑制法检测的选定精油的抗活性。
Molecules. 2019 Sep 11;24(18):3301. doi: 10.3390/molecules24183301.

引用本文的文献

1
Green Extraction of Volatile Terpenes from L.从罗勒中绿色提取挥发性萜类化合物
Molecules. 2025 Apr 7;30(7):1638. doi: 10.3390/molecules30071638.
2
A Screen of Traditional Chinese Medicinal Plant Extracts Reveals 17 Species with Antimicrobial Properties.一项对传统中药植物提取物的筛选揭示了17种具有抗菌特性的物种。
Antibiotics (Basel). 2024 Dec 17;13(12):1220. doi: 10.3390/antibiotics13121220.
3
L. polysaccharide improves the growth performance and intestinal barrier function of broilers challenged with .罗伊氏乳杆菌多糖可改善受……挑战的肉鸡的生长性能和肠道屏障功能。 （注：原文中“challenged with”后面似乎缺失了具体内容）

本文引用的文献

1
Cytotoxic Action of Artemisinin and Scopoletin on Planktonic Forms and on Biofilms of Species.青蒿素和东莨菪内酯对浮游形式和物种生物膜的细胞毒性作用。
Molecules. 2020 Jan 22;25(3):476. doi: 10.3390/molecules25030476.
2
Essential oils of increase membrane permeability, disturb cell membrane integrity, and suppress quorum-sensing phenotype in bacteria.精油可增加细胞膜通透性，破坏细胞膜完整性，并抑制细菌群体感应表型。
J Pharm Anal. 2019 Oct;9(5):301-311. doi: 10.1016/j.jpha.2019.03.001. Epub 2019 Mar 7.
3
Antimicrobial Activity of Chamomile Essential Oil: Effect of Different Formulations.
Front Microbiol. 2024 Apr 30;15:1390815. doi: 10.3389/fmicb.2024.1390815. eCollection 2024.
4
(Vaill.) L.: Micromorphology, Essential Oil Composition, and Its Potential as an Alternative Biocontrol Product.（瓦伊尔）L.：微观形态学、精油成分及其作为替代生物防治产品的潜力。
Plants (Basel). 2024 Mar 13;13(6):825. doi: 10.3390/plants13060825.
5
Antibacterial activity and mechanism of cinnamon essential oil nanoemulsion against CM2.肉桂精油纳米乳对CM2的抗菌活性及作用机制
Heliyon. 2023 Aug 28;9(9):e19582. doi: 10.1016/j.heliyon.2023.e19582. eCollection 2023 Sep.
6
Five Different L. Species Ethanol Extracts' Phytochemical Composition and Their Antimicrobial and Nematocide Activity.五种不同 L. 物种乙醇提取物的植物化学成分及其抗菌和杀线虫活性。
Int J Mol Sci. 2023 Sep 21;24(18):14372. doi: 10.3390/ijms241814372.
7
Antibacterial effect of essential oils and their components against pv. revealed by microdilution and direct bioautographic assays.精油及其成分对 pv 的抑菌作用通过微量稀释和直接生物自显影测定法揭示。
Front Cell Infect Microbiol. 2023 Jun 14;13:1204027. doi: 10.3389/fcimb.2023.1204027. eCollection 2023.
8
Phytochemistry, Pharmacology and Mode of Action of the Anti-Bacterial Plants.抗菌植物的植物化学、药理学及作用方式
Bioengineering (Basel). 2023 May 23;10(6):633. doi: 10.3390/bioengineering10060633.
9
Evaluation of gene expression related to immunity, apoptosis, and gut integrity that underlies 's therapeutic effects in necrotic enteritis-challenged broilers.评估与免疫、细胞凋亡和肠道完整性相关的基因表达，这些基因表达是坏死性肠炎攻毒肉鸡治疗效果的基础。
3 Biotech. 2023 Jun;13(6):181. doi: 10.1007/s13205-023-03560-9. Epub 2023 May 12.
10
Nanotechnology Promoting the Development of Products from the Biodiversity of the Asteraceae Family.纳米技术促进菊科植物生物多样性产品的开发。
Nutrients. 2023 Mar 26;15(7):1610. doi: 10.3390/nu15071610.
香菊精油的抗菌活性：不同配方的影响。
Molecules. 2019 Nov 26;24(23):4321. doi: 10.3390/molecules24234321.
4
Application of a Multisystem Coating Based on Polymeric Nanocapsules Containing Essential Oil of Thymus Vulgaris L. to Increase the Shelf Life of Table Grapes (Vitis Vinifera L.).基于含百里香精油的聚合物纳米胶囊的多系统涂层在提高鲜食葡萄（Vitis Vinifera L.）货架期中的应用。
IEEE Trans Nanobioscience. 2019 Oct;18(4):549-557. doi: 10.1109/TNB.2019.2941931. Epub 2019 Sep 26.
5
Longevity is determined by ETS transcription factors in multiple tissues and diverse species.端粒长度由多个组织和多种物种中的 ETS 转录因子决定。
PLoS Genet. 2019 Jul 29;15(7):e1008212. doi: 10.1371/journal.pgen.1008212. eCollection 2019 Jul.
6
Antioxidant and antimicrobial properties of randomly methylated β cyclodextrin - captured essential oils.随机甲基化β-环糊精捕获的精油的抗氧化和抗菌性能。
Food Chem. 2019 Apr 25;278:305-313. doi: 10.1016/j.foodchem.2018.11.047. Epub 2018 Nov 9.
7
Essential Oils and Their Vapors as Potential Antibacterial Agents against Respiratory Tract Pathogens.精油及其蒸汽作为抗呼吸道病原体的潜在抗菌剂
Nat Prod Commun. 2016 Nov;11(11):1709-1712.
8
Essential oils as alternatives to antibiotics in swine production.香精油作为猪生产中抗生素的替代品
Anim Nutr. 2018 Jun;4(2):126-136. doi: 10.1016/j.aninu.2017.09.001. Epub 2017 Sep 18.
9
Antifungal Activity of Essential Oil Compounds (Geraniol and Citral) and Inhibitory Mechanisms on Grain Pathogens ( and ).精油化合物（香叶醇和柠檬醛）的抗真菌活性及其对谷物病原菌（和）的抑制机制。
Molecules. 2018 Aug 22;23(9):2108. doi: 10.3390/molecules23092108.
10
Reprogramming Yeast Metabolism from Alcoholic Fermentation to Lipogenesis.重编程酵母代谢从酒精发酵到脂肪生成。
Cell. 2018 Sep 6;174(6):1549-1558.e14. doi: 10.1016/j.cell.2018.07.013. Epub 2018 Aug 9.