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1
Impact of environmental pollution on the ocular surface of Sjögren's syndrome patients.环境污染对干燥综合征患者眼表的影响。
Arq Bras Oftalmol. 2018;81(6):481-489. doi: 10.5935/0004-2749.20180091. Epub 2018 Sep 13.
2
Candida albicans and Early Childhood Caries: A Systematic Review and Meta-Analysis.白色念珠菌与幼儿龋病：系统评价和荟萃分析。
Caries Res. 2018;52(1-2):102-112. doi: 10.1159/000481833. Epub 2017 Dec 21.
3
A qualitative exploration of physical, mental and ocular fatigue in patients with primary Sjögren's Syndrome.原发性干燥综合征患者身体、精神和眼部疲劳的质性探索
PLoS One. 2017 Oct 31;12(10):e0187272. doi: 10.1371/journal.pone.0187272. eCollection 2017.
4
The British Society for Rheumatology guideline for the management of adults with primary Sjögren's Syndrome.英国风湿病学会原发性干燥综合征成人管理指南。
Rheumatology (Oxford). 2017 Oct 1;56(10):e24-e48. doi: 10.1093/rheumatology/kex166.
5
Cutaneous and Mucosal Manifestations of Sjögren's Syndrome.干燥综合征的皮肤和黏膜表现。
Clin Rev Allergy Immunol. 2017 Dec;53(3):357-370. doi: 10.1007/s12016-017-8639-y.
6
Are the women with Sjögren's Syndrome satisfied with their sexual activity?干燥综合征女性对其性活动满意吗？
Rev Bras Reumatol Engl Ed. 2017 May-Jun;57(3):210-216. doi: 10.1016/j.rbre.2017.01.002. Epub 2017 Feb 8.
7
Subjective and Objective Measures of Dryness Symptoms in Primary Sjögren's Syndrome: Capturing the Discrepancy.原发性干燥综合征干燥症状的主观和客观测量：捕捉差异
Arthritis Care Res (Hoboken). 2017 Nov;69(11):1714-1723. doi: 10.1002/acr.23165. Epub 2017 Oct 9.
8
Status of Removable Dentures and Relationship with Oral Candida-Associated Factors in a Geriatric Population in Catalonia.加泰罗尼亚老年人群可摘义齿状况及其与口腔念珠菌相关因素的关系。
J Prosthodont. 2017 Jul;26(5):370-375. doi: 10.1111/jopr.12551. Epub 2016 Oct 6.
9
A randomized, double-blind, placebo-controlled clinical trial of fluoride varnish in preventing dental caries of Sjögren's syndrome patients.一项关于氟化物清漆预防干燥综合征患者龋齿的随机、双盲、安慰剂对照临床试验。
BMC Oral Health. 2016 Sep 23;16(1):102. doi: 10.1186/s12903-016-0296-7.
10
Chronic Pruritus in Primary Sjögren's Syndrome: Characteristics and Effect on Quality of Life.原发性干燥综合征中的慢性瘙痒：特征及其对生活质量的影响。
Acta Derm Venereol. 2017 Mar 10;97(3):385-386. doi: 10.2340/00015555-2524.

干燥症状、口腔健康状况、唾液流量和口腔 在干燥综合征患者中的表现。

Sicca Symptoms, Oral Health Conditions, Salivary Flow and Oral in Sjögren's Syndrome Patients.

机构信息

Department of Stomatology, Shantou University Medical College, Shantou 515041, China.

Faculty of Dentistry, The University of Hong Kong, Pok Fu Lam, Hong Kong.

出版信息

Int J Environ Res Public Health. 2020 May 21;17(10):3625. doi: 10.3390/ijerph17103625.

DOI:10.3390/ijerph17103625
PMID:32455849
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7277231/
Abstract

This study aimed to investigate the relationships among sicca symptoms, oral health conditions, salivary profiles and oral Candida in Sjögren's syndrome (SS) patients. Eighty-five SS patients (mean age = 50.5) and 40 healthy non-SS individuals (mean age = 51.4) were recruited. They self-completed the Sicca Symptoms Inventory (SSI). Decayed, missing and filled surface (DMFS) scores, salivary flow rates, pH and oral Candida colonization were determined. Mean SSI summary scores of SS patients and non-SS individuals were 11.1 and 5.4 respectively ( < 0.001). The most prevalent sicca symptoms in SS patients were eye irritation (93%), dry throat or nose (88%) and need of fluid for mouth wetting (88%). SS patients had significantly lower whole salivary flow rates than the non-SS individuals. Candida strains were isolated from over 60% of SS patients but not in non-SS patients. C. albicans was the predominant species. SSI summary score was negatively correlated to salivary flow rates while SSI summary and domain scores were positively correlated to the number of filled surfaces (FS) and DMFS scores and oral Candida counts. In conclusion, SS patients had more severe sicca symptoms than non-SS individuals. SSI scores were negatively correlated to the salivary flow rates but positively correlated to caries experience and oral Candida colonization.

摘要

本研究旨在探讨干燥综合征（SS）患者的干燥症状、口腔健康状况、唾液状况和口腔念珠菌之间的关系。招募了 85 名 SS 患者（平均年龄=50.5）和 40 名健康的非 SS 个体（平均年龄=51.4）。他们自行完成了干燥症状量表（SSI）。测定了龋齿、缺失和补牙的表面数（DMFS）、唾液流率、pH 值和口腔念珠菌定植。SS 患者和非 SS 个体的平均 SSI 总分分别为 11.1 和 5.4（<0.001）。SS 患者最常见的干燥症状是眼刺激（93%）、咽干或鼻干（88%）和需要液体湿润口腔（88%）。SS 患者的全唾液流率明显低于非 SS 个体。念珠菌菌株从超过 60%的 SS 患者中分离出来，但在非 SS 患者中没有分离出来。白色念珠菌是主要的物种。SSI 总分与唾液流率呈负相关，而 SSI 总分和各领域评分与补牙数（FS）和 DMFS 评分以及口腔念珠菌计数呈正相关。总之，SS 患者的干燥症状比非 SS 个体更严重。SSI 评分与唾液流率呈负相关，但与龋齿发病和口腔念珠菌定植呈正相关。