Graduate School of Science and Technology, Shizuoka University, Shizuoka, Japan.
Research Institute of Green Science and Technology, Shizuoka University, Shizuoka, Japan.
J Antibiot (Tokyo). 2020 Oct;73(10):733-736. doi: 10.1038/s41429-020-0323-4. Epub 2020 May 27.
A novel compound (1) and three known ones (2-4) were isolated from the fruiting bodies of Pleurocybella porrigens. The structure of the novel compound was determined by 1D and 2D NMR and HRESIMS data. The biological activity of 1-3 was evaluated using the A549 lung cancer cell line. The results showed the inhibitory activity of compounds 1-3 on the expression of Axl and immune checkpoint molecules.
从猪苓的子实体中分离得到一种新的化合物（1）和三种已知化合物（2-4）。新化合物的结构通过 1D 和 2D NMR 以及 HRESIMS 数据确定。采用 A549 肺癌细胞系评价了 1-3 的生物活性。结果表明，化合物 1-3 对 Axl 和免疫检查点分子的表达具有抑制活性。
