杠柳和来源于头序鹅膏的免疫检查点抑制剂。
Axl and immune checkpoints inhibitors from fruiting bodies of Pleurocybella porrigens.
机构信息
Graduate School of Science and Technology, Shizuoka University, Shizuoka, Japan.
Research Institute of Green Science and Technology, Shizuoka University, Shizuoka, Japan.
出版信息
J Antibiot (Tokyo). 2020 Oct;73(10):733-736. doi: 10.1038/s41429-020-0323-4. Epub 2020 May 27.
A novel compound (1) and three known ones (2-4) were isolated from the fruiting bodies of Pleurocybella porrigens. The structure of the novel compound was determined by 1D and 2D NMR and HRESIMS data. The biological activity of 1-3 was evaluated using the A549 lung cancer cell line. The results showed the inhibitory activity of compounds 1-3 on the expression of Axl and immune checkpoint molecules.
从猪苓的子实体中分离得到一种新的化合物（1）和三种已知化合物（2-4）。新化合物的结构通过 1D 和 2D NMR 以及 HRESIMS 数据确定。采用 A549 肺癌细胞系评价了 1-3 的生物活性。结果表明，化合物 1-3 对 Axl 和免疫检查点分子的表达具有抑制活性。
Zotero 插件