Prevention and Epidemiology Research Center of Non-Communicable Disease, Health Faculty, Shahid Saduoghi University of Medical Sciences, Yazd, Iran.
Department of Public Health, School of Medicine, Dezful University of Medical Sciences, Dezful, Iran.
Asian Pac J Cancer Prev. 2020 May 1;21(5):1487-1494. doi: 10.31557/APJCP.2020.21.5.1487.
Cancer is the second leading cause of death in children under 15 and leukemia is the most common type of cancer in this age group. The aim of the present study is to investigate the incidence and mortality of leukemia in children aged 0-14 years and its relationship with Human Development Index (HDI in different countries of the world. Methods: Incidence and mortality rates were obtained from GLOBOCAN and Country's income from World Bank. The data analysis was conducted using correlation analysis. The association of incidence and mortality rates with HDI was investigated using linear regression models.
The results revealed a significant positive correlation between the incidence rate and Gross National Income per capita (r = 0.464, P <0.0001), mean years of schooling (r = 0.566, P <0.0001), life expectancy at birth (r = 0.712, P <0.0001) and expected years of schooling (r = 0.604, P <0.0001). The results also demonstrated a positive and significant correlation between mortality rate and life expectancy at birth (r = 0.199, P <0.0001). An improvement in HDI [Beta = 7.7, CI95% (0.1, 15.3)] and life Expectancy at birth [Beta = 0.1, CI95% (0.03, 0.1)] caused a significantly rise in the incidence of leukemia. Moreover, the improved HDI [Beta = 6.2, CI95% (1.9, 10.5)] was associated with increased mean years of schooling [Beta = -0.1, CI95% (-0.2, -0.01)] and expected years of schooling [Beta = -0.1, CI95% (-0.3, -0.08).
As the HDI increases, incidence and mortality from of leukemia increases indicating a change in factors that affects leukemia incidences.
癌症是 15 岁以下儿童的第二大死亡原因，白血病是该年龄段最常见的癌症类型。本研究旨在调查世界不同国家 0-14 岁儿童白血病的发病率和死亡率及其与人类发展指数（HDI）的关系。
发病率和死亡率数据来自 GLOBOCAN 和世界银行的国家收入。使用相关分析进行数据分析。使用线性回归模型研究发病率和死亡率与 HDI 的关系。
结果显示，发病率与人均国民总收入（r = 0.464，P <0.0001）、平均受教育年限（r = 0.566，P <0.0001）、出生预期寿命（r = 0.712，P <0.0001）和预期受教育年限（r = 0.604，P <0.0001）呈显著正相关。结果还表明，死亡率与出生预期寿命呈正相关（r = 0.199，P <0.0001）。HDI 的提高[β=7.7，95%CI（0.1，15.3）]和出生预期寿命的提高[β=0.1，95%CI（0.03，0.1）]导致白血病发病率显著上升。此外，HDI 的改善[β=6.2，95%CI（1.9，10.5）]与平均受教育年限的增加[β=-0.1，95%CI（-0.2，-0.01）]和预期受教育年限的增加[β=-0.1，95%CI（-0.3，-0.08）]有关。
随着 HDI 的增加，白血病的发病率和死亡率也随之增加，这表明影响白血病发病率的因素发生了变化。
