血清维生素 D、钙与中国妇女子宫肌瘤的关系：一项病例对照研究。
The associations between serum vitamin D, calcium and uterine fibroids in Chinese women: a case-controlled study.
机构信息
Department of Obstetrics and Gynaecology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
出版信息
J Int Med Res. 2020 May;48(5):300060520923492. doi: 10.1177/0300060520923492.
OBJECTIVE
To investigate the associations between serum vitamin D, calcium and uterine fibroids in a Chinese female population.
METHODS
In this case-control study, adult female patients with fibroids (cases) were compared with females without fibroids (controls) in terms of serum 25-hydroxyvitamin D (25OHD) and calcium levels.
RESULTS
Out of 546 total participants (mean age, 41.68 ± 5.99 years; 279 with fibroids and 267 without fibroids), only 232 had serum 25OHD levels above the sufficient threshold (>20 ng/ml). In addition, females with fibroids had lower serum 25OHD levels versus those without fibroids. The prevalence of fibroids in females with deficient (<12 ng/ml) and insufficient (12-20 ng/ml) 25OHD levels were significantly higher than in females with sufficient (>20 ng/ml) 25OHD levels. Serum calcium levels were within normal range in both groups.
CONCLUSION
Hypovitaminosis D was highly prevalent among a population of Chinese females of reproductive-age, and serum 25OHD levels were lower in female patients with fibroids.
目的
在中国女性人群中研究血清维生素 D、钙与子宫肌瘤之间的关系。
方法
在这项病例对照研究中，将患有子宫肌瘤的成年女性患者（病例）与无子宫肌瘤的女性（对照）进行比较，比较内容为血清 25-羟维生素 D（25OHD）和钙水平。
结果
在 546 名总参与者（平均年龄 41.68±5.99 岁；279 名患有子宫肌瘤，267 名无子宫肌瘤）中，仅有 232 人的血清 25OHD 水平超过充足阈值（>20ng/ml）。此外，患有子宫肌瘤的女性血清 25OHD 水平低于无子宫肌瘤的女性。血清 25OHD 水平不足（<12ng/ml）和不足够（12-20ng/ml）的女性中子宫肌瘤的患病率明显高于血清 25OHD 水平充足（>20ng/ml）的女性。两组血清钙水平均在正常范围内。
结论
在中国育龄女性人群中，普遍存在维生素 D 缺乏症，且患有子宫肌瘤的女性患者血清 25OHD 水平较低。
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