Adeboje-Jimoh Fatimah, Okunade Kehinde Sharafadeen, Olorunfemi Gbenga, Olamijulo Joseph Ayodeji
Lagos University Teaching Hospital.
University of Witwatersrand.
Res Sq. 2023 May 4:rs.3.rs-2877359. doi: 10.21203/rs.3.rs-2877359/v1.
Studies have suggested the potential roles of serum trace elements such as calcium and magnesium in the development of uterine fibroids. This study compared magnesium and calcium serum levels in reproductive-age women with and without uterine fibroids in Lagos, Southwest Nigeria. A comparative cross-sectional study of 194 parity-matched women with or without a sonographic diagnosis of uterine fibroids enrolled at a university teaching hospital in Lagos, Southwest Nigeria. Participants' sociodemographic, ultrasound, and anthropometric information as well as the estimated serum levels of calcium and magnesium were collected for statistical analyses. This study found significant negative associations between low serum calcium levels and uterine fibroids (adjusted odds ratio= 0.06; 95% CI: 0.004, 0.958; p=0.047), uterine size (p=0.004), and the number of fibroid nodules (p=0.030). However, no significant association was observed between serum magnesium levels and uterine fibroids (p=0.341). The findings of this study suggest the promising role of calcium-rich diets and supplements in the prevention of uterine fibroids among Nigerian women. However, future longitudinal studies are required to further evaluate the potential role of these trace mineral elements in the development of uterine fibroids.
研究表明，血清微量元素如钙和镁在子宫肌瘤的发生发展中可能发挥作用。本研究比较了尼日利亚西南部拉各斯有和没有子宫肌瘤的育龄妇女的血清镁和钙水平。这是一项在尼日利亚西南部拉各斯的一家大学教学医院开展的比较性横断面研究，纳入了194名经超声诊断有或没有子宫肌瘤的经产匹配妇女。收集了参与者的社会人口统计学、超声和人体测量学信息以及估计的血清钙和镁水平，用于统计分析。本研究发现，血清钙水平低与子宫肌瘤（调整优势比=0.06；95%置信区间：0.004，0.958；p=0.047）、子宫大小（p=0.004）和肌瘤结节数量（p=0.030）之间存在显著负相关。然而，未观察到血清镁水平与子宫肌瘤之间存在显著关联（p=0.341）。本研究结果表明，富含钙的饮食和补充剂在尼日利亚妇女预防子宫肌瘤方面可能发挥作用。然而，需要未来的纵向研究来进一步评估这些微量矿物质元素在子宫肌瘤发生发展中的潜在作用。
