School of Public Health, Kunming Medical University, Kunming, China.
Institute for Acute Communicable Disease Prevention and Control, Yunnan Provincial Center for Disease Control and Prevention, Kunming, Yunnan, China.
BMJ Open. 2023 Nov 28;13(12):e073592. doi: 10.1136/bmjopen-2023-073592.
Sedentary behaviour is associated with a variety of adverse health outcomes, including obesity, oestrogen metabolism and chronic inflammation, all of which are related to the pathogenesis of uterine fibroids (UFs). This study aimed to explore the relationship between leisure sedentary time (LST) and UFs.
Cross-sectional.
We conducted a cross-sectional analysis of data from patients from the Yunnan region in the China Multi-Ethnic Cohort Study.
A total of 6623 non-menopausal women aged 30-55 years old were recruited. Menstrual status was self-reported. Participants who lacked a unique national identity card, suffered from serious mental illness, did not have a clear diagnosis of UFs, or provided incomplete information were excluded.
UFs were diagnosed by abdominal B-ultrasound. Leisure sedentary behaviour was assessed by using a face-to-face questionnaire interview. Logistic regression and restricted cubic spline were employed to explore the relationship between LST and UFs.
A total of 562 participants had UFs, with a prevalence rate of 8.5% (7.8%, 9.2%). Multivariate adjusted logistic regression analysis showed that the risk of UFs in women with LST≥6 hour/day was 2.008 times that in women with LST<2 hour/day (95% CI 1.230 to 3.279). The restricted cubic spline results showed that there was a linear dose‒response relationship between LST and UFs (p for non-linearity>0.05). According to the results of the stratified analysis for menstrual status and body mass index (BMI), there was a correlation between LST and the prevalence of UFs only in women with a BMI<24 kg/m or perimenopause.
LST was independently associated with the prevalence of UFs, and a linear dose‒response relationship was observed. Our study provides evidence on the factors influencing UFs, and further research is needed to propose feasible measures for UFs prevention.
久坐行为与多种不良健康后果有关，包括肥胖、雌激素代谢和慢性炎症，所有这些都与子宫肌瘤（UFs）的发病机制有关。本研究旨在探讨休闲久坐时间（LST）与 UFs 之间的关系。
横断面研究。
我们对来自中国多民族队列研究云南地区的患者进行了一项横断面分析。
共招募了 6623 名年龄在 30-55 岁之间的非绝经妇女。月经状况由自我报告。排除了缺乏唯一的国家身份证、患有严重精神疾病、UFs 诊断不明确或提供不完整信息的参与者。
UFs 通过腹部 B 超诊断。休闲久坐行为通过面对面问卷调查进行评估。采用 logistic 回归和限制性立方样条分析来探讨 LST 与 UFs 之间的关系。
共有 562 名参与者患有 UFs，患病率为 8.5%（7.8%，9.2%）。多变量调整后的 logistic 回归分析显示，LST≥6 小时/天的女性患 UFs 的风险是 LST<2 小时/天的女性的 2.008 倍（95%CI 1.230 至 3.279）。限制性立方样条结果表明，LST 与 UFs 之间存在线性剂量-反应关系（p 非线性>0.05）。根据月经状况和体重指数（BMI）的分层分析结果，只有 BMI<24kg/m 或围绝经期的女性中，LST 与 UFs 的患病率之间存在相关性。
LST 与 UFs 的患病率独立相关，且呈线性剂量-反应关系。本研究提供了影响 UFs 的因素的证据，需要进一步研究以提出可行的 UFs 预防措施。
