Hannigan J H, Riley E P
Center for Behavioral Teratology, State University of New York, Albany 12222.
Alcohol. 1988 Nov-Dec;5(6):451-4. doi: 10.1016/0741-8329(88)90081-x.
Rats exposed to ethanol in utero were assessed for changes in gait at 55 days of age. Ethanol-exposed animals had significantly shorter stride lengths, more open step angles, and less gait symmetry than control rats. There were no differences in stance width or apparent speed. This pattern of changes in motor function indicates that prenatal exposure to ethanol produces long-lasting "ataxia" in rats. These results closely resemble previous findings of altered gait following neonatal ethanol exposure in rats, as well as clinical findings in some FAS children. The results are consistent with an hypothesis of prenatal ethanol-induced disruption of functional hippocampal and/or cerebellar development. Ataxia and gait dysfunction may be sensitive indicators of ethanol teratogenesis.
对子宫内暴露于乙醇的大鼠在55日龄时进行步态变化评估。与对照大鼠相比，暴露于乙醇的动物步幅明显更短，步角更开阔，步态对称性更低。站立宽度或表观速度没有差异。这种运动功能变化模式表明，产前暴露于乙醇会在大鼠中产生持久的“共济失调”。这些结果与先前关于大鼠新生儿期乙醇暴露后步态改变的研究结果以及一些胎儿酒精谱系障碍（FAS）儿童的临床研究结果非常相似。这些结果与产前乙醇诱导功能性海马体和/或小脑发育破坏的假说一致。共济失调和步态功能障碍可能是乙醇致畸作用的敏感指标。
