The Framingham Heart Study, Framingham, Massachusetts, USA.
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.
Mov Disord. 2020 Aug;35(8):1475-1481. doi: 10.1002/mds.28092. Epub 2020 May 27.
Idiopathic rapid eye movement sleep behavior disorder is associated with increased risk of neurodegeneration, but the temporal evolution of regional perfusion, a marker of cerebral activity, has not been characterized. The objective of the current study was to study longitudinal regional perfusion in patients with idiopathic rapid eye movement sleep behavior disorder.
Thirty-seven patients and 23 controls underwent high-resolution single-photon emission computed tomography. After 17 months on average, scans were repeated for idiopathic rapid eye movement sleep behavior disorder patients. We compared regional cerebral blood flow between groups and over time.
At baseline, patients showed lower relative regional perfusion in the anterior frontal and lateral parietotemporal cortex compared with controls. However, over time, patients showed an increase in relative regional perfusion in the anterior frontal, lateral parietal, and occipitotemporal cortex, reverting toward normal control levels.
Patients with idiopathic rapid eye movement sleep behavior disorder showed significant areas of relative regional hypoperfusion, which disappeared over time to finally return to average levels, suggesting possible developing compensation in areas affected by neurodegeneration. © 2020 International Parkinson and Movement Disorder Society.
特发性快速眼动睡眠行为障碍与神经退行性变风险增加相关，但脑活动标志物——区域性灌注的时间演变尚未得到明确。本研究旨在研究特发性快速眼动睡眠行为障碍患者的纵向区域性灌注。
37 名患者和 23 名对照者接受了高分辨率单光子发射计算机断层扫描。特发性快速眼动睡眠行为障碍患者平均 17 个月后再次进行扫描。我们比较了组间和随时间的区域性脑血流。
基线时，患者的前额和外侧顶颞叶皮质的相对区域性灌注低于对照组。然而，随时间推移，患者的前额、外侧顶叶和枕颞叶皮质的相对区域性灌注增加，恢复到正常对照水平。
特发性快速眼动睡眠行为障碍患者存在明显的相对区域性灌注不足区域，这些区域随时间逐渐消失，最终恢复到平均水平，提示受神经退行性变影响的区域可能存在潜在的代偿。© 2020 国际帕金森病和运动障碍学会。
