迈向植物源抗癌药物的微生物生产。
Towards the Microbial Production of Plant-Derived Anticancer Drugs.
机构信息
Biomolécules et Biotechnologies Végétales, BBV, EA2106, Université de Tours, Tours, France.
Department of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, Jena, Germany.
出版信息
Trends Cancer. 2020 Jun;6(6):444-448. doi: 10.1016/j.trecan.2020.02.004. Epub 2020 Mar 5.
Many of the plant-derived compounds used in chemotherapies are currently produced by semisynthesis, which results in limited supplies at exorbitant market prices. However, the synthetic biology era, which began ca 15 years ago, has progressively yielded encouraging advances by using engineered microbes for the practical production of cheaper plant anticancer drugs.
许多用于化疗的植物衍生化合物目前通过半合成生产，这导致供应有限，且市场价格过高。然而，大约 15 年前开始的合成生物学时代，通过使用工程微生物来实际生产更便宜的植物抗癌药物，已经取得了令人鼓舞的进展。
Zotero 插件