Centre for Advanced Studies in Botany, University of Madras, Chennai 600 025, India.
Department of Pharmacology, Prince Sattam Bin Abdul Aziz University, Al-Kharj 11942, Kingdom of Saudi Arabia.
IET Nanobiotechnol. 2020 Jun;14(4):314-324. doi: 10.1049/iet-nbt.2019.0116.
Nanomedicine is an interdisciplinary approach that involves toxicology and other medicinal applications. Gold nanoparticles (AuNPs) may serve as a promising model to address the size and shape-dependent biological response because they show good biocompatibility. This study is to prepare phytosynthesis AuNPs from ten different sp. Among them, the aqueous leaf extract of produced greater efficient and stable AuNPs. The AuNPs were optimised for different physicochemical conditions. Highly stable AuNPs were synthesised at pH 7.0, 37°C, 1.0 ml of leaf extract and 1.0 mM concentration of HAuCl with the particle size of ∼50 nm and these AuNPs were stable up to 12 months. To determine the safety profile of AuNPs , the nanoparticles were injected intravenously into male Wistar albino rats in varying dosages. The authors noticed no significant difference in body weights, haematological and biochemical parameters and the histopathological sections of all vital organs. Highest accumulation was seen in spleen and least in brain. The authors' results show that the AuNPs were biocompatible and did not produce any adverse or abnormalities . The implications of the bioaccumulation of AuNPs need to be further studied to rule out any adverse effects on long-term exposure.
纳米医学是一种涉及毒理学和其他医学应用的跨学科方法。金纳米粒子（AuNPs）可以作为一种有前途的模型来解决尺寸和形状依赖性的生物学反应，因为它们表现出良好的生物相容性。本研究从十种不同的 sp. 中制备植物合成 AuNPs。其中， 的叶水提物产生了更高效和稳定的 AuNPs。AuNPs 被优化用于不同的物理化学条件。在 pH 7.0、37°C、1.0 ml 叶提取物和 1.0 mM HAuCl 浓度下合成了高度稳定的 AuNPs，粒径约为 50nm，这些 AuNPs 稳定可达 12 个月。为了确定 AuNPs 的安全性，将纳米颗粒以不同剂量静脉注射到雄性 Wistar 白化大鼠体内。作者注意到体重、血液学和生化参数以及所有重要器官的组织病理学切片均无显著差异。在脾脏中的积累最高，在大脑中最低。作者的结果表明，AuNPs 具有生物相容性，不会产生任何不良反应或异常。需要进一步研究 AuNPs 的生物累积，以排除长期暴露可能产生的任何不良反应。
