Riomet Margaux, Porte Karine, Wijkhuisen Anne, Audisio Davide, Taran Frédéric
Université Paris Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SCBM, 91191 Gif-sur-Yvette, France.
Chem Commun (Camb). 2020 Jul 4;56(52):7183-7186. doi: 10.1039/d0cc03067h. Epub 2020 May 28.
In this article, we report the synthesis and use of iminosydnone-based profluorophores as bioorthogonal cleavable linkers for imaging applications. These linkers react with cycloalkynes via subsequent [3+2] cycloaddition and retro Diels-Alder reactions, allowing simultaneous release of two dyes in biological media.
在本文中，我们报道了基于亚胺基 sydnone 的前体荧光团作为用于成像应用的生物正交可裂解连接子的合成及应用。这些连接子通过后续的 [3+2] 环加成反应和逆 Diels-Alder 反应与环炔烃发生反应，从而能够在生物介质中同时释放两种染料。
