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杂环型一氧化氮供体的合成及生物医学应用的最新进展。

Recent Advances in the Synthesis and Biomedical Applications of Heterocyclic NO-Donors.

机构信息

Laboratory of Nitrogen Compounds, N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prosp., 47, 119991 Moscow, Russia.

出版信息

Molecules. 2021 Sep 21;26(18):5705. doi: 10.3390/molecules26185705.

DOI:10.3390/molecules26185705
PMID:34577175
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8470015/
Abstract

Nitric oxide (NO) is a key signaling molecule that acts in various physiological processes such as cellular metabolism, vasodilation and transmission of nerve impulses. A wide number of vascular diseases as well as various immune and neurodegenerative disorders were found to be directly associated with a disruption of NO production in living organisms. These issues justify a constant search of novel NO-donors with improved pharmacokinetic profiles and prolonged action. In a series of known structural classes capable of NO release, heterocyclic NO-donors are of special importance due to their increased hydrolytic stability and low toxicity. It is no wonder that synthetic and biochemical investigations of heterocyclic NO-donors have emerged significantly in recent years. In this review, we summarized recent advances in the synthesis, reactivity and biomedical applications of promising heterocyclic NO-donors (furoxans, sydnone imines, pyridazine dioxides, azasydnones). The synthetic potential of each heterocyclic system along with biochemical mechanisms of action are emphasized.

摘要

一氧化氮（NO）是一种关键的信号分子，在细胞代谢、血管舒张和神经冲动传递等各种生理过程中发挥作用。大量的血管疾病以及各种免疫和神经退行性疾病都被发现与生物体内 NO 产生的中断直接相关。这些问题证明了需要不断寻找具有改善的药代动力学特征和延长作用的新型 NO 供体。在一系列能够释放 NO 的已知结构类别中，由于其增加的水解稳定性和低毒性，杂环 NO 供体具有特殊的重要性。难怪近年来，杂环 NO 供体的合成和生化研究显著增加。在这篇综述中，我们总结了有前途的杂环 NO 供体（呋咱、 sydnone 亚胺、哒嗪二氧化物、氮杂 sydnone）的合成、反应性和生物医学应用方面的最新进展。强调了每个杂环体系的合成潜力以及生化作用机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5df0/8470015/6a9def19f9b4/molecules-26-05705-sch013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5df0/8470015/e7ca1405c3f2/molecules-26-05705-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5df0/8470015/45966858d099/molecules-26-05705-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5df0/8470015/2ba09f941319/molecules-26-05705-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5df0/8470015/c116c23a52d5/molecules-26-05705-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5df0/8470015/eafd71231dbf/molecules-26-05705-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5df0/8470015/d676658dd0f2/molecules-26-05705-sch004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5df0/8470015/4152a5c9572c/molecules-26-05705-sch005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5df0/8470015/4fd77fe9bbca/molecules-26-05705-sch006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5df0/8470015/f46f2e8a24d3/molecules-26-05705-sch007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5df0/8470015/932c24a5b8d7/molecules-26-05705-sch009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5df0/8470015/7aed3b494cb0/molecules-26-05705-sch010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5df0/8470015/fd495df5e944/molecules-26-05705-sch011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5df0/8470015/9af35bc5afbd/molecules-26-05705-sch012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5df0/8470015/6a9def19f9b4/molecules-26-05705-sch013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5df0/8470015/e7ca1405c3f2/molecules-26-05705-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5df0/8470015/45966858d099/molecules-26-05705-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5df0/8470015/2ba09f941319/molecules-26-05705-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5df0/8470015/c116c23a52d5/molecules-26-05705-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5df0/8470015/eafd71231dbf/molecules-26-05705-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5df0/8470015/d676658dd0f2/molecules-26-05705-sch004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5df0/8470015/4152a5c9572c/molecules-26-05705-sch005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5df0/8470015/4fd77fe9bbca/molecules-26-05705-sch006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5df0/8470015/f46f2e8a24d3/molecules-26-05705-sch007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5df0/8470015/932c24a5b8d7/molecules-26-05705-sch009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5df0/8470015/7aed3b494cb0/molecules-26-05705-sch010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5df0/8470015/fd495df5e944/molecules-26-05705-sch011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5df0/8470015/9af35bc5afbd/molecules-26-05705-sch012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5df0/8470015/6a9def19f9b4/molecules-26-05705-sch013.jpg

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本文引用的文献

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